POLD2

POLD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3E0J
Identifiers
Aliases	POLD2, DNA polymerase delta 2, accessory subunit
External IDs	OMIM: 600815; MGI: 1097163; HomoloGene: 4538; GeneCards: POLD2; OMA:POLD2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,124,358 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	5,828,292 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of liver; ; body of pancreas; ; skin of abdomen; ; ganglionic eminence; ; anterior pituitary; ; gastrocnemius muscle; ; left uterine tube; ; tibial nerve; ; popliteal artery;
	Top expressed in
	yolk sac; ; internal carotid artery; ; maxillary prominence; ; external carotid artery; ; medial ganglionic eminence; ; abdominal wall; ; primitive streak; ; dermis; ; endocardial cushion; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; DNA-directed DNA polymerase activity;
Cellular component	nucleoplasm; nucleus; delta DNA polymerase complex;
Biological process	nucleotide-excision repair, DNA gap filling; DNA replication; translesion synthesis; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; telomere maintenance; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA repair; DNA strand elongation involved in DNA replication; cellular response to DNA damage stimulus; telomere maintenance via semi-conservative replication; DNA mismatch repair; DNA biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	5425
	18972
	ENSG00000106628
	ENSMUSG00000020471
	P49005
	O35654
	NM_001127218; NM_001256879; NM_006230
	NM_008894; NM_001361942
	NP_001120690; NP_001243808; NP_006221
	NP_032920; NP_001348871
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene.^[5]^[6] It is a component of the DNA polymerase delta complex.

Template:PBB Summary

Interactions

POLD2 has been shown to interact with PCNA.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106628 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020471 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang J, Tan CK, McMullen B, Downey KM, So AG (Feb 1996). "Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)". Genomics. 29 (1): 179–86. doi:10.1006/geno.1995.1229. PMID 8530069.
^ "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa".
^ Lu, Xiaoqing; Tan Cheng-Keat; Zhou Jin-Qiu; You Min; Carastro L Michael; Downey Kathleen M; So Antero G (Jul 2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. 277 (27). United States: 24340–5. doi:10.1074/jbc.M200065200. ISSN 0021-9258. PMID 11986310. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading