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Proquazone

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Proquazone
Clinical data
ATC code
Identifiers
  • 1-isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.041.079 Edit this at Wikidata
Chemical and physical data
FormulaC18H18N2O
Molar mass278.34832 g/mol g·mol−1
3D model (JSmol)
  • CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=CC=C3
  • InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3 ☒N
  • Key:JTIGKVIOEQASGT-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Proquazone is a non-steroidal anti-inflammatory drug.[1]

Synthesis

[2] [3]

References

  1. ^ Clissold, S. P.; Beresford, R. (1987). "Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states". Drugs. 33 (5): 478–502. doi:10.2165/00003495-198733050-00004. PMID 3297621.
  2. ^ Coombs, R. V.; Danna, R. P.; Denzer, M.; Hardtmann, G. E.; Huegi, B.; Koletar, G.; Koletar, J.; Ott, H.; Jukniewicz, E. (1973). "Synthesis and antiinflammatory activity of 1-alkyl-4-aryl-2(1H)-quinazolines and quinazolinethiones". Journal of Medicinal Chemistry. 16 (11): 1237–1245. doi:10.1021/jm00269a006. ISSN 0022-2623.
  3. ^ G. Gamboni, W. Schmid and A. Sutter; GB1592687 (1981 to Sandoz).


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