|Preferred IUPAC name
Salicin; D-(−)-Salicin; Salicoside; 2-(Hydroxymethyl)phenyl
CompTox Dashboard (EPA)
|Molar mass||286.280 g·mol−1|
|Melting point||197 to 200 °C (387 to 392 °F; 470 to 473 K)|
|4.3 g/100 mL|
|Solubility in Ethanol||0.3g/100 mL|
|Solubility in DMSO||2 g/100mL|
|Solubility in dimethyl formamide||3 g/100mL|
|Occupational safety and health (OHS/OSH):|
|Skin sensitizer / Contact dermatitis|
|P261, P272, P280, P302+P352, P333+P313, P362, P363, P501|
|NFPA 704 (fire diamond)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
what is ?)(
Salicin is found in the bark of and leaves of willows, poplars and various other plants. Derivates are found in castoreum. Salicin from meadowsweet was used in the synthesis of aspirin (acetylsalicylic acid), in 1899 by scientists at Bayer. Salicin tastes bitter like quinine.
Salicin may cause an allergic skin reaction (skin sensitization; category 1).
Mild side effects are standard, with rare occurrences of nausea, vomiting, rash, dizziness and breathing problems. Overdose from high quantities of salicin can be toxic, damaging kidneys, causing stomach ulcers, diarrhea, bleeding or digestive discomfort. Some people may be allergic or sensitive to salicylates and suffer reactions similar to those produced by aspirin. People should not take salicin if they have asthma, diabetes, gout, gastritis, hemophilia, stomach ulcers; also contraindicated are children under 16, and pregnant and breastfeeding women.
- Merck Index, 11th Edition, 8293
- Pasteels, J. M.; Rowell-Rahier, M.; Braekman, J. C.; Dupont, A. (1983). "Salicin from host plant as precursor of salicylaldehyde in defensive secretion of Chrysomeline larvae". Physiological Entomology. 8 (3): 307–314. doi:10.1111/j.1365-3032.1983.tb00362.x. S2CID 85066862.
- "History of Aspirin". About.com Inventors. Retrieved 2016-06-15.
- Daniells, S (2006-10-09). "Symrise explores cheaper alternatives in bitter-maskers". www.foodnavigator.com. Retrieved 2007-12-13.
- "Willow bark | University of Maryland Medical Center". Archived from the original on 2013-10-30. Retrieved 2013-10-21.