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Clinical data
ATC code
CAS Number
PubChem CID
ECHA InfoCard 100.012.133
Chemical and physical data
Formula C9H11NO2
Molar mass 165.189 g/mol
3D model (Jmol)

Ethenzamide is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.[1][2] It is an ingredient in numerous cold medications and many prescription analgesics.[citation needed]

Mechanism of Action[edit]

Ethionamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organism. Ethionamide, like prothionamide and pyrazinamide, is a nicotinic acid derivative related to isoniazid. It is thought that ethionamide undergoes intracellular modification and acts in a similar fashion to isoniazid. Isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. Specifically isoniazid inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.[3]


  1. ^ Darias, V.; Bravo, L.; Abdallah, S. S.; Sánchez Mateo, C. C.; Expósito-Orta, M. A.; Lissavetsky, J.; Manzanares, J. (1992). "Synthesis and preliminary pharmacological study of thiophene analogues of the antipyretic and analgesic agent ethenzamide". Archiv der Pharmazie. 325 (2): 83–87. doi:10.1002/ardp.19923250206. PMID 1605721. 
  2. ^ Wang, P. J.; Guo, H. R. (2004). "Frequent analgesics consumption in migraineurs: Comparison between chronic and episodic migraineurs". The Journal of Headache and Pain. 5: 30. doi:10.1007/s10194-004-0065-x. 
  3. ^ DrugBank, ed. (2016-08-17). "Ethionamide". DrugBank.