|Systematic (IUPAC) name|
|Trade names||Disalcid, Salflex|
|Molar mass||258.23 g/mol|
|(what is this?)|
Salsalate is a medication that belongs to the salicylate and non-steroidal anti-inflammatory drug (NSAID) classes. Relative to other NSAIDs, salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several proinflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein. The mechanism through which salsalate is thought to reduce the production of these inflammatory chemical signals is through the inhibition of IκB kinase resulting in decreased action of NF-κB genes. This mechanism is thought to be responsible for salsalate's insulin-sensitizing and blood sugar lowering properties. Salsalate is the generic name of a prescription drug marketed under the brandnames Mono-Gesic, Salflex, Disalcid, and Salsitab. Other generic and brand name formulations may be available.
Salsalate has been proposed for the prevention and treatment of type 2 diabetes mellitus due to its ability to lower insulin resistance associated with inflammation and may be useful in prediabetes. However, the use of salsalate to prevent the progression from prediabetes to type 2 diabetes mellitus has received limited study.
Unquestionably, the most frequently used analgesic is aspirin. The reader will recall that aspirin is regarded as a latentiated form of salicyclic acid and is intented to minimize as far as possible the irritation of the gastrointestinal tract that salicyclic acid would otherwise cause. Salsalate represents another approach to this problem in which self-esterification has been used to serve the same purpose. Direct self-condensation is difficult to control, although low temperature treatment of salicylic acid with PCl3 does work.
A more stepwise procedure involves the condensation of benzyl salicylate (1) with the acid chloride of salicyclate benzyl ether 2 to produce protected dimer 3. Catalytic hydrogenation removes the benzyl groups and completes the preparation of salsalate (4).
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- drugs.com Salsalate entry
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