Sulfotransferase

Sulfotransferases EC 2.8.2.- are transferase enzymes that catalyze the transfer of a sulfo group from a donor molecule to an acceptor alcohol or amine.^[1] The most common sulfo group donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS). In the case of alcohol as acceptor, the product is a sulfate (R-OSO₃⁻), whereas an amine leads to a sulfamate (R-NH-SO₃⁻). Both reactive groups for a sulfonation via sulfotransferases may be part of a protein, lipid, carbohydrate or steroid.^[2]

Examples

The following are examples of sulfotransferases:

carbohydrate sulfotransferase: CHST1, CHST2, CHST3, CHST4, CHST5, CHST6, CHST7, CHST8, CHST9, CHST10, CHST11, CHST12, CHST13, CHST14
galactose-3-O-sulfotransferase: GAL3ST1, GAL3ST2, GAL3ST3, GAL3ST4
heparan sulfate 2-O-sulfotransferase: HS2ST1,
heparan sulfate 3-O-sulfotransferase: HS3ST1, HS3ST2, HS3ST3A1, HS3ST3A2, HS3ST3B1, HS3ST3B2, HS3ST4, HS3ST5, HS3ST6
heparan sulfate 6-O-sulfotransferase: HS6ST1, HS6ST2, HS6ST3
N-deacetylase/N-sulfotransferase: NDST1, NDST2, NDST3, NDST4
tyrosylprotein sulfotransferase: TPST1, TPST2
uronyl-2-sulfotransferase
Estrone sulfotransferase
Chondroitin 4-sulfotransferase
other: SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1B1, SULT1C2, SULT1C3, SULT1C4, SULT1D1P, SULT1E1, SULT2A1, SULT2B1, SULT4A1, SULT6B1

References

^ Negishi M; Pedersen LG; Petrotchenko E; et al. (2001). "Structure and function of sulfotransferases". Arch. Biochem. Biophys. 390 (2): 149–57. doi:10.1006/abbi.2001.2368. PMID 11396917. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
^ Rath VL, Verdugo D, Hemmerich S (2004). "Sulfotransferase structural biology and inhibitor discovery". Drug Discov. Today. 9 (23): 1003–11. doi:10.1016/S1359-6446(04)03273-8. PMID 15574316.

External links

Sulfotransferases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[1] Negishi M; Pedersen LG; Petrotchenko E; et al. (2001). "Structure and function of sulfotransferases". Arch. Biochem. Biophys. 390 (2): 149–57. doi:10.1006/abbi.2001.2368. PMID 11396917. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[2] Rath VL, Verdugo D, Hemmerich S (2004). "Sulfotransferase structural biology and inhibitor discovery". Drug Discov. Today. 9 (23): 1003–11. doi:10.1016/S1359-6446(04)03273-8. PMID 15574316.

[1]

[2]

v t e Transferases: sulfur-containing group (EC 2.8)
2.8.1: Sulfurtransferases	Thiosulfate sulfurtransferase Rhodanese 3-mercaptopyruvate sulfurtransferase thiosulfate—thiol sulfurtransferase tRNA sulfurtransferase thiosulfate—dithiol sulfurtransferase biotin synthase cysteine desulfurase
2.8.2: Sulfotransferases	Alcohol sulfotransferase Tyrosylprotein sulfotransferase Aryl sulfotransferase
2.8.3: CoA-transferases	Propionate CoA-transferase
2.8.4: Alkylthio	Coenzyme-B sulfoethylthiotransferase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Examples

See also

References

External links