Suppressor of cytokine signaling 1

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Aliases SOCS1, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, suppressor of cytokine signaling 1
External IDs MGI: 1354910 HomoloGene: 2776 GeneCards: SOCS1
Genetically Related Diseases
psoriasis, Crohn's disease[1]
RNA expression pattern
PBB GE SOCS1 209999 x at fs.png

PBB GE SOCS1 210001 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 16: 11.25 – 11.26 Mb Chr 16: 10.78 – 10.79 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene.[4][5] SOCS1 orthologs [6] have been identified in several mammals for which complete genome data are available.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.[7]

See also[edit]


Suppressor of cytokine signaling 1 has been shown to interact with:


  1. ^ "Diseases that are genetically associated with SOCS1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A (August 1995). "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors". EMBO J. 14 (12): 2816–26. PMC 398400Freely accessible. PMID 7796808. 
  5. ^ Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (September 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833. 
  6. ^ "OrthoMaM phylogenetic marker: SOCS1 coding sequence". 
  7. ^ "Entrez Gene: SOCS1 suppressor of cytokine signaling 1". 
  8. ^ De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R (February 1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". EMBO J. 18 (4): 904–15. doi:10.1093/emboj/18.4.904. PMC 1171183Freely accessible. PMID 10022833. 
  9. ^ Bourette RP, De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G (June 2001). "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal". J. Biol. Chem. 276 (25): 22133–9. doi:10.1074/jbc.M101878200. PMID 11297560. 
  10. ^ Ram PA, Waxman DJ (Dec 1999). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". J. Biol. Chem. 274 (50): 35553–61. doi:10.1074/jbc.274.50.35553. PMID 10585430. 
  11. ^ Rui L, Yuan M, Frantz D, Shoelson S, White MF (November 2002). "SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2". J. Biol. Chem. 277 (44): 42394–8. doi:10.1074/jbc.C200444200. PMID 12228220. 
  12. ^ Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A (March 1999). "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop". EMBO J. 18 (5): 1309–20. doi:10.1093/emboj/18.5.1309. PMC 1171221Freely accessible. PMID 10064597. 
  13. ^ Dif F, Saunier E, Demeneix B, Kelly PA, Edery M (Dec 2001). "Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor". Endocrinology. 142 (12): 5286–93. doi:10.1210/endo.142.12.8549. PMID 11713228. 
  14. ^ Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A (June 1997). "A new protein containing an SH2 domain that inhibits JAK kinases". Nature. 387 (6636): 921–4. doi:10.1038/43213. PMID 9202126. 
  15. ^ Pezet A, Favre H, Kelly PA, Edery M (August 1999). "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling". J. Biol. Chem. 274 (35): 24497–502. doi:10.1074/jbc.274.35.24497. PMID 10455112. 
  16. ^ Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O (May 2002). "Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1". Mol. Cell. Biol. 22 (10): 3316–26. doi:10.1128/mcb.22.10.3316-3326.2002. PMC 133778Freely accessible. PMID 11971965. 
  17. ^ Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (October 1997). "Cloning and characterization of novel CIS family genes". Biochem. Biophys. Res. Commun. 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848. 
  18. ^ Ohya Ki; Kajigaya S; Yamashita Y; Miyazato A; Hatake K; Miura Y; Ikeda U; Shimada K; Ozawa K; Mano H (October 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID 9341160. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.