This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is [(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase. Other names in common use include XEG, xyloglucan endo-beta-1,4-glucanase, xyloglucanase, xyloglucanendohydrolase, XH, and 1,4-beta-D-glucan glucanohydrolase.
Family 12 was first identified in plant pathogens by discovery in Phytophthora spp.
Pauly M; Andersen, LN; Kauppinen, S; Kofod, LV; York, WS; Albersheim, P; Darvill, A (1999). "A xyloglucan-specific endo-beta-1,4-glucanase from Aspergillus aculeatus: expression cloning in yeast, purification and characterization of the recombinant enzyme". Glycobiology. 9 (1): 93–100. doi:10.1093/glycob/9.1.93. PMID9884411.
Sinitsyn AP; Gusakov, AV; Markov, AV; Ustinov, BB; Semenova, MV; Sinitsyn, AP (2004). "Specific xyloglucanases as a new class of polysaccharide-degrading enzymes". Biochim. Biophys. Acta. 1674 (3): 268–81. doi:10.1016/j.bbagen.2004.07.001. PMID15541296.
Costanzo, Stefano; M.D. Ospina-Giraldo; R.W. Jones (2006). "Gene duplication event in family 12 glycosyl hydrolase from Phytophthora spp". Fungal Genetics and Biology. 43 (10): 707–714. doi:10.1016/j.fgb.2006.04.006. PMID16784880.