^[a] The 49ers acquired an additional second-round selection (No. 56 overall) as part of a trade that sent quarterbackAlex Smith to the Kansas City Chiefs. The Chiefs originally sent a third-round selection to the 49ers, however, the selection was upgraded to a second-rounder after a condition was met in which the Chiefs won a minimum of eight games during the 2013 season.
^[b] The Broncos traded their second- and fifth-round selections in 2014 (Nos. 63 and 171 overall, respectively) as well a fifth-round selection in the 2015 NFL Draft to the 49ers in exchange for a second- and seventh-round selection (Nos. 56 and 242 overall).
^[c] The 49ers traded the second- and fifth-round selections they acquired from Denver[b] to Miami in exchange for Miami's second-round selection (No. 57 overall)
^[d]Jacksonville traded their third- and fifth-round selections (Nos. 70 and 150 overall) to the 49ers in exchange for the 49ers second-round selection (No. 61 overall).
^[e] The 49ers acquired an additional third-round selection (No. 77 overall) as part of a trade that sent their 2013 third-round selection to the Tennessee Titans.
^[f]Cleveland traded their fourth- and sixth-round selections (Nos. 106 and 180 overall) to the 49ers in exchange for the 49ers third-round selection (No. 95 overall).
Networks and times for Sunday games from Weeks 5–17 are subject to change as a result of flexible scheduling.
^[a] The exact kickoff time and network for Week 16 will be determined at a later date. If the game airs on the NFL Network, the kickoff will be 1:30 p.m. PST, and will be simulcast on a local station to be determined. If the game airs on CBS, the kickoff will be 5:00 p.m. PST.
In November 2013, Levi's Stadium and 49ers' officials initially requested the NFL to not schedule any weekday home games during the preseason or regular season — including Monday and Thursday Night Football — during Levi's Stadium's inaugural season, due to parking issues in the Santa Clara area during weekdays. Two months later (January 2014), the Santa Clara City Council approved a two-year deal with the Santa Clara Golf & Tennis Club that would have opened up 10,000 additional parking spaces within walking distance of Levi's Stadium, as well as reimbursed the club $250,000 for each year, which would have enabled the team to host Monday and Thursday night games for both the 2014 and 2015 seasons. However, the NFL decided not to schedule any weeknight prime-time games at Levi's Stadium during the 2014 season, for the exception of the Week 13 Thanksgiving game, until traffic flow within the area is figured out.