From Wikipedia, the free encyclopedia
Jump to: navigation, search
Virus classification
Group: Group III (dsRNA)
Family: Birnaviridae


Birnavirus RNA dependent RNA polymerase (VP1)
Symbol Birna_RdRp
Pfam PF04197
InterPro IPR007100
Birnavirus VP2 protein
PDB 2df7 EBI.jpg
crystal structure of infectious bursal disease virus vp2 subviral particle
Symbol Birna_VP2
Pfam PF01766
Pfam clan CL0055
InterPro IPR002662
Birnavirus VP3 protein
Symbol Birna_VP3
Pfam PF01767
InterPro IPR002663
Birnavirus VP4 protein
Symbol Birna_VP4
Pfam PF01768
InterPro IPR002664
Birnavirus VP5 protein
Symbol Birna_VP5
Pfam PF03042
InterPro IPR004284

The Birnaviridae are a family of viruses, including the following genera:

The Birnaviridae are type-III viruses in the Baltimore classification, which means they have a double-stranded RNA genome. The other family of type-III viruses is the Reoviridae.

Birnaviridae proteins[edit]

The Birnaviridae genome encodes several proteins:

The Birnaviridae RNA-directed RNA polymerase (VP1), which lacks the highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RNA-directed RNA polymerases.[1]

The large RNA segment, segment A, of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [2] that is processed into the major structural proteins of the virion: VP2, VP3 (a minor structural component of the virus), and into the putative protease VP4.[2] VP4 protein is involved in generating VP2 and VP3.[2] recombinant VP3 is more immunogenic than recombinant VP2.[3]

Infectious pancreatic necrosis virus (IPNV), a birnavirus, is an important pathogen in fish farms. Analyses of viral proteins showed that VP2 is the major structural and immunogenic polypeptide of the virus.[4][5] All neutralizing monoclonal antibodies are specific to VP2 and bind to continuous or discontinuous epitopes. The variable domain of VP2 and the 20 adjacent amino acids of the conserved C-terminal are probably the most important in inducing an immune response for the protection of animals.[4]

Non structural protein VP5 is found in RNA segment A. The function of this small viral protein is unknown. It is believed to be involved in influencing apoptosis, but studies are not completely concurring. The protein can not be found in the virion.


The family includes a number of viruses:

Chicken proventricular necrosis virus


  1. ^ Shwed PS, Dobos P, Cameron LA, Vakharia VN, Duncan R (May 2002). "Birnavirus VP1 proteins form a distinct subgroup of RNA-dependent RNA polymerases lacking a GDD motif". Virology 296 (2): 241–50. doi:10.1006/viro.2001.1334. PMID 12069523. 
  2. ^ a b c Jagadish MN, Staton VJ, Hudson PJ, Azad AA (March 1988). "Birnavirus precursor polyprotein is processed in Escherichia coli by its own virus-encoded polypeptide". J. Virol. 62 (3): 1084–7. PMC 253673. PMID 2828658. 
  3. ^ Moon CH, Do JW, Cha SJ, Bang JD, Park MA, Yoo DJ, Lee JM, Kim HG, Chung DK, Park JW (October 2004). "Comparison of the immunogenicity of recombinant VP2 and VP3 of infectious pancreatic necrosis virus and marine birnavirus". Arch. Virol. 149 (10): 2059–68. PMID 15669113. 
  4. ^ a b Heppell J, Tarrab E, Lecomte J, Berthiaume L, Arella M (December 1995). "Strain variability and localization of important epitopes on the major structural protein (VP2) of infectious pancreatic necrosis virus". Virology 214 (1): 40–9. doi:10.1006/viro.1995.9956. PMID 8525637. 
  5. ^ Nobiron I, Galloux M, Henry C, Torhy C, Boudinot P, Lejal N, Da Costa B, Delmas B (February 2008). "Genome and polypeptides characterization of Tellina virus 1 reveals a fifth genetic cluster in the Birnaviridae family". Virology 371 (2): 350–61. doi:10.1016/j.virol.2007.09.022. PMID 17976679. 

External links[edit]

This article incorporates text from the public domain Pfam and InterPro IPR002664

This article incorporates text from the public domain Pfam and InterPro IPR002663

This article incorporates text from the public domain Pfam and InterPro IPR004284

This article incorporates text from the public domain Pfam and InterPro IPR002662

This article incorporates text from the public domain Pfam and InterPro IPR007100