|Group:||Group II (ssDNA)|
The genome is monopartite, circular, single-stranded DNA of between 1.8 to 3.8 kilobases. There are two main open reading frames arranged in opposite directions that encode the replication (Rep) and capsid (Cap) proteins. Alternative start codons are common in the avian species.
The viruses replicate their genomes via a rolling circle mechanism. A stem loop structure with a conserved nonanucleotide motif is located at the 5' intergenic region of circovirus genomes and is thought to initiate rolling-cycle replication.
Two circoviruses have been identified in fish—Barbel circovirus (BaCV) 1 and 2. Their genomes are in length and contain two major open reading frames similar to the capsid and replication associated protein genes found in other circoviruses.
- Genus Circovirus: type species: Porcine circovirus type 1 and 2, beak and feather disease virus (BFDV)
A cyclovirus—cyclovirus-Vietnam—has been isolated from the cerebrospinal fluid of 25 Vietnamese patients with CNS infections of unknown aetiology. The same virus has been isolated from the faeces of healthy children and also from pigs and chickens. This suggests an orofaecal route of transmission with a possible animal reservoir.
- Lorincz M, Csagola A, Farkas SL, Szekely C, Tuboly T (2011) First detection and analysis of a fish circovirus. J Gen Virol
- Mankertz P (2008). "Molecular Biology of Porcine Circoviruses". Animal Viruses: Molecular Biology. Caister Academic Press. ISBN 978-1-904455-22-6.
- Dayaram A, Potter KA, Moline AB, Rosenstein DD, Marinov M, Thomas JE, Beitbart M, Rosario K, Argüello-Astorga GR, Varsani A (2013) High global diversity of cycloviruses amongst dragonflies. J Gen Virol
- Tan le V, van Doorn HR, Nghia HD, Chau TT, Tu le TP, de Vries M, Canuti M, Deijs M, Jebbink MF, Baker S, Bryant JE, Tham NT, Bkrong NT, Boni MF, Loi TQ, Phuong le T, Verhoeven JT, Crusat M, Jeeninga RE, Schultsz C, Chau NV, Hien TT, van der Hoek L, Farrar J, de Jong MD (2013) Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. MBio 4(3). pii: e00231–13. doi: 10.1128/mBio.00231-13
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