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Nuclear receptor coactivator 4
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NCOA4 ; ARA70; ELE1; PTC3; RFG
External IDs OMIM601984 MGI1350932 HomoloGene38052 GeneCards: NCOA4 Gene
RNA expression pattern
PBB GE NCOA4 210774 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8031 27057
Ensembl ENSG00000138293 ENSMUSG00000056234
UniProt Q13772 E9PVM8
RefSeq (mRNA) NM_001145260 NM_001033988
RefSeq (protein) NP_001138732 NP_001029160
Location (UCSC) Chr 10:
51.57 – 51.59 Mb
Chr 14:
32.16 – 32.18 Mb
PubMed search [1] [2]

Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.[1][2][3]


NCOA4 has been shown to interact with:

See also[edit]


  1. ^ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (February 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene 9 (2): 509–16. PMID 8290261. 
  2. ^ a b Yeh S, Chang C (July 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proc Natl Acad Sci U S A 93 (11): 5517–21. doi:10.1073/pnas.93.11.5517. PMC 39278. PMID 8643607. 
  3. ^ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4". 
  4. ^ Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B (January 1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Mol. Endocrinol. 13 (1): 117–28. doi:10.1210/mend.13.1.0214. PMID 9892017. 
  5. ^ Miyamoto H, Yeh S, Wilding G, Chang C (June 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157. 
  6. ^ Lin HK, Yeh S, Kang HY, Chang C (June 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7200–5. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460. 
  7. ^ Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905. 
  8. ^ Zhou ZX, He B, Hall SH, Wilson EM, French FS (February 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Mol. Endocrinol. 16 (2): 287–300. doi:10.1210/mend.16.2.0765. PMID 11818501. 
  9. ^ He B, Minges JT, Lee LW, Wilson EM (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". J. Biol. Chem. 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876. 
  10. ^ Gao T, Brantley K, Bolu E, McPhaul MJ (October 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Mol. Endocrinol. 13 (10): 1645–56. doi:10.1210/mend.13.10.0352. PMID 10517667. 
  11. ^ He B, Wilson EM (March 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084. 
  12. ^ Heinlein CA, Ting HJ, Yeh S, Chang C (June 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". J. Biol. Chem. 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.