From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ring finger protein 14
Symbols RNF14 ; ARA54; HFB30; TRIAD2
External IDs OMIM605675 MGI1929668 HomoloGene129170 GeneCards: RNF14 Gene
RNA expression pattern
PBB GE RNF14 201823 s at tn.png
PBB GE RNF14 201824 at tn.png
More reference expression data
Species Human Mouse
Entrez 9604 56736
Ensembl ENSG00000013561 ENSMUSG00000060450
UniProt Q9UBS8 Q9JI90
RefSeq (mRNA) NM_001201365 NM_001164621
RefSeq (protein) NP_001188294 NP_001158093
Location (UCSC) Chr 5:
141.96 – 141.99 Mb
Chr 18:
38.3 – 38.32 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.[1][2][3]


The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.[3]


RNF14 has been shown to interact with the Androgen receptor.[1][4][5][6]

See also[edit]


  1. ^ a b Kang HY, Yeh S, Fujimoto N, Chang C (Apr 1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". J Biol Chem 274 (13): 8570–6. doi:10.1074/jbc.274.13.8570. PMID 10085091. 
  2. ^ Ueki N, Seki N, Yano K, Masuho Y, Saito T, Muramatsu M (Jun 1999). "Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif". Biochim Biophys Acta 1445 (2): 232–6. doi:10.1016/s0167-4781(99)00045-7. PMID 10320776. 
  3. ^ a b "Entrez Gene: RNF14 ring finger protein 14". 
  4. ^ Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC et al. (Feb 2002). "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth". J. Biol. Chem. 277 (7): 4609–17. doi:10.1074/jbc.M108312200. PMID 11673464. 
  5. ^ He B, Minges JT, Lee LW, Wilson EM (Mar 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". J. Biol. Chem. 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876. 
  6. ^ He B, Wilson EM (Mar 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.