Nuclear receptor coactivator 3

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Nuclear receptor coactivator 3
Protein NCOA3 PDB 1kbh.png
NCOA3 activation domain 1 (AD1) bound to a portion of CBP. PDB rendering based on 1kbh.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NCOA3 ; ACTR; AIB-1; AIB1; CAGH16; CTG26; KAT13B; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1; bHLHe42; pCIP
External IDs OMIM601937 MGI1276535 HomoloGene4764 ChEMBL: 1615382 GeneCards: NCOA3 Gene
EC number 2.3.1.48
RNA expression pattern
PBB GE NCOA3 207700 s at tn.png
PBB GE NCOA3 209060 x at tn.png
PBB GE NCOA3 209062 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8202 17979
Ensembl ENSG00000124151 ENSMUSG00000027678
UniProt Q9Y6Q9 O09000
RefSeq (mRNA) NM_001174087 NM_008679
RefSeq (protein) NP_001167558 NP_032705
Location (UCSC) Chr 20:
46.13 – 46.29 Mb
Chr 2:
165.99 – 166.07 Mb
PubMed search [1] [2]

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene.[1][2] NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Function[edit]

NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.[3][4]

Clinical significance[edit]

The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.[5][6]

Interactions[edit]

Nuclear receptor coactivator 3 has been shown to interact with DDX17,[7] IKK2,[8] Androgen receptor,[9][10][11] CREB-binding protein,[8][12] Glucocorticoid receptor,[13][14] Peroxisome proliferator-activated receptor gamma,[15] IKBKG,[8] Estrogen receptor alpha,[7][16][17] Estrogen receptor beta,[16][18] DDX5,[7] CHUK[8] and Retinoid X receptor alpha.[19][20]

References[edit]

  1. ^ Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (August 1997). "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer". Science 277 (5328): 965–8. doi:10.1126/science.277.5328.965. PMID 9252329. 
  2. ^ Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (October 1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1". J. Biol. Chem. 272 (44): 27629–34. doi:10.1074/jbc.272.44.27629. PMID 9346901. 
  3. ^ Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (1997). "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer". Science 277 (5328): 965–8. doi:10.1126/science.277.5328.965. PMID 9252329. 
  4. ^ Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1". J Biol Chem 272 (44): 27629–34. doi:10.1074/jbc.272.44.27629. PMID 9346901. 
  5. ^ "Study sheds new light on tamoxifen resistance". Cordis News. Cordis. 2008-11-13. Retrieved 2008-11-14. 
  6. ^ Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, Jiang J, Howat WJ, Ali S, Carroll JS (December 2008). "Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen". Nature 456 (7222): 663–6. doi:10.1038/nature07483. PMC 2920208. PMID 19005469. 
  7. ^ a b c Watanabe, M; Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (March 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. (England) 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. ISSN 0261-4189. PMC 145523. PMID 11250900. 
  8. ^ a b c d Wu, Ray-Chang; Qin Jun, Hashimoto Yoshihiro, Wong Jiemin, Xu Jianming, Tsai Sophia Y, Tsai Ming-Jer, O'Malley Bert W (May 2002). "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase". Mol. Cell. Biol. (United States) 22 (10): 3549–61. doi:10.1128/MCB.22.10.3549-3561.2002. ISSN 0270-7306. PMC 133790. PMID 11971985. 
  9. ^ Tan, J A; Hall S H, Petrusz P, French F S (September 2000). "Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator". Endocrinology (UNITED STATES) 141 (9): 3440–50. doi:10.1210/en.141.9.3440. ISSN 0013-7227. PMID 10965917. 
  10. ^ Gnanapragasam, V J; Leung H Y, Pulimood A S, Neal D E, Robson C N (December 2001). "Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer". Br. J. Cancer (Scotland) 85 (12): 1928–36. doi:10.1054/bjoc.2001.2179. ISSN 0007-0920. PMC 2364015. PMID 11747336. 
  11. ^ Wang, Qianben; Udayakumar T S, Vasaitis Tadas S, Brodie Angela M, Fondell Joseph D (April 2004). "Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells". J. Biol. Chem. (United States) 279 (17): 17319–28. doi:10.1074/jbc.M400970200. ISSN 0021-9258. PMID 14966121. 
  12. ^ Naltner, A; Wert S, Whitsett J A, Yan C (December 2000). "Temporal/spatial expression of nuclear receptor coactivators in the mouse lung". Am. J. Physiol. Lung Cell Mol. Physiol. (UNITED STATES) 279 (6): L1066–74. ISSN 1040-0605. PMID 11076796. 
  13. ^ Hsiao, Pei-Wen; Fryer Christy J, Trotter Kevin W, Wang Weidong, Archer Trevor K (September 2003). "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation". Mol. Cell. Biol. (United States) 23 (17): 6210–20. doi:10.1128/MCB.23.17.6210-6220.2003. ISSN 0270-7306. PMC 180928. PMID 12917342. 
  14. ^ Zilliacus, J; Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson J A (April 2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140". Mol. Endocrinol. (United States) 15 (4): 501–11. doi:10.1210/me.15.4.501. ISSN 0888-8809. PMID 11266503. 
  15. ^ Kodera, Y; Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S (October 2000). "Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators". J. Biol. Chem. (UNITED STATES) 275 (43): 33201–4. doi:10.1074/jbc.C000517200. ISSN 0021-9258. PMID 10944516. 
  16. ^ a b Wong, C W; Komm B, Cheskis B J (June 2001). "Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands". Biochemistry (United States) 40 (23): 6756–65. doi:10.1021/bi010379h. ISSN 0006-2960. PMID 11389589. 
  17. ^ Tikkanen, M K; Carter D J, Harris A M, Le H M, Azorsa D O, Meltzer P S, Murdoch F E (November 2000). "Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (23): 12536–40. doi:10.1073/pnas.220427297. ISSN 0027-8424. PMC 18799. PMID 11050174. 
  18. ^ Leo, C; Li H, Chen J D (February 2000). "Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3". J. Biol. Chem. (UNITED STATES) 275 (8): 5976–82. doi:10.1074/jbc.275.8.5976. ISSN 0021-9258. PMID 10681591. 
  19. ^ Chen, H; Lin R J, Schiltz R L, Chakravarti D, Nash A, Nagy L, Privalsky M L, Nakatani Y, Evans R M (August 1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300". Cell (UNITED STATES) 90 (3): 569–80. doi:10.1016/S0092-8674(00)80516-4. ISSN 0092-8674. PMID 9267036. 
  20. ^ Lee, Wen-yi; Noy Noa (February 2002). "Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain". Biochemistry (United States) 41 (8): 2500–8. doi:10.1021/bi011764. ISSN 0006-2960. PMID 11851396. 

External links[edit]

Further reading[edit]