Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3gene. BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.
The BCAS3 gene is regulated by estrogen receptor alpha (ER-α). The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α. Furthermore BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.
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Gururaj AE, Peng S, Vadlamudi RK, Kumar R (2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol.21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID17505058.