BCAS3

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Breast carcinoma amplified sequence 3
Identifiers
Symbols BCAS3 ; GAOB1; MAAB
External IDs OMIM607470 MGI2385848 HomoloGene9778 GeneCards: BCAS3 Gene
RNA expression pattern
PBB GE BCAS3 220488 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 54828 192197
Ensembl ENSG00000141376 ENSMUSG00000059439
UniProt Q9H6U6 Q8CCN5
RefSeq (mRNA) NM_001099432 NM_001166642
RefSeq (protein) NP_001092902 NP_001160114
Location (UCSC) Chr 17:
58.75 – 59.47 Mb
Chr 11:
85.35 – 85.83 Mb
PubMed search [1] [2]

Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene.[1][2] BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.[2]

Function[edit]

The BCAS3 gene is regulated by estrogen receptor alpha (ER-α).[3] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α.[4] Furthermore BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.[4]

References[edit]

  1. ^ "Entrez Gene: BCAS3 breast carcinoma amplified sequence 3". 
  2. ^ a b Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A (December 2002). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer 35 (4): 311–7. doi:10.1002/gcc.10121. PMID 12378525. 
  3. ^ Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R (April 2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. doi:10.1073/pnas.0601989103. PMC 1458939. PMID 16617102. 
  4. ^ a b Gururaj AE, Peng S, Vadlamudi RK, Kumar R (August 2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID 17505058. 

Further reading[edit]