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In the past, it was noted by the US that Meridia was a harmless medication for fighting obesity. The [[US District Court]] of the Northern District of Ohio rejected 113 cases complaining about the negative effects of the medication, stating that the clients lacked supporting facts and that the representatives involved were not qualified enough.<ref>{{cite journal|last=Obesity, Fitness & Wellness Week|title=Legal Issues; Court dismisses claims against anti-obesity medication|date=14 August 2004|url=http://bf4dv7zn3u.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info:sid/summon.serialssolutions.com&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Abbott+Laboratories%3B+Court+dismisses+claims+against+anti-obesity+medication&rft.jtitle=Biotech+Week&rft.date=2004-08-11&rft.issn=1535-2757&rft.spage=11&rft.externalDBID=BIOT&rft.externalDocID=674298481|accessdate=9 April 2012}}</ref>
In the past, it was noted by the US that Meridia was a harmless medication for fighting obesity. The [[US District Court]] of the Northern District of Ohio rejected 113 cases complaining about the negative effects of the medication, stating that the clients lacked supporting facts and that the representatives involved were not qualified enough.<ref>{{cite journal|last=Obesity, Fitness & Wellness Week|title=Legal Issues; Court dismisses claims against anti-obesity medication|date=14 August 2004|url=http://bf4dv7zn3u.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info:sid/summon.serialssolutions.com&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Abbott+Laboratories%3B+Court+dismisses+claims+against+anti-obesity+medication&rft.jtitle=Biotech+Week&rft.date=2004-08-11&rft.issn=1535-2757&rft.spage=11&rft.externalDBID=BIOT&rft.externalDocID=674298481|accessdate=9 April 2012}}</ref>


Sibutramine has been withdrawn from the market in the United States,<ref name="wsj">{{cite news|last=Rockoff|first=Jonathan D.|last2=Dooren|first2=Jennifer Corbett|title=Abbott Pulls Diet Drug Meridia Off US Shelves |url=https://www.wsj.com/article/BT-CO-20101008-710904.html |accessdate=8 October 2010|newspaper=The Wall Street Journal|date=8 October 2010| archiveurl= https://web.archive.org/web/20101011004015/http://online.wsj.com/article/BT-CO-20101008-710904.html| archivedate= 11 October 2010 | url-status= live}}</ref> the UK,<ref>{{cite news | url=http://news.bbc.co.uk/1/hi/health/8473555.stm |title=Top obesity drug sibutramine being suspended |accessdate=22 January 2010 |work=BBC News |date=22 January 2010| archiveurl= https://web.archive.org/web/20100125005254/http://news.bbc.co.uk/1/hi/health/8473555.stm| archivedate= 25 January 2010 | url-status= live}}</ref> the EU,<ref>{{in lang|de}} Sibutramin-Vertrieb in der Europäischen Union ausgesetzt [http://www.abbott.de/content/e17/e127/e15940/index_de.html] {{Webarchive|url=https://archive.today/20120719155409/http://www.abbott.de/content/e17/e127/e15940/index_de.html |date=19 July 2012 }}. [[Abbott Laboratories]] in Germany. [[Press Release]] 2010-01-21. Retrieved 2010-01-27</ref> Australia,<ref>{{cite web|url=http://sibutramine.com/australia/en-au/ |title=Sibutramine (brand name Reductil) Information – Australia |year=2010 |accessdate=8 October 2010 |publisher=Abbott Laboratories |archiveurl=https://web.archive.org/web/20101014014348/http://sibutramine.com/australia/en-au/ |archivedate=14 October 2010 |url-status=dead }}</ref> Canada,<ref>{{cite web|url=http://hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/prof/_2010/meridia_hpc-cps-eng.php|title=MedEffect Canada - Advisories, Warnings and Recalls - Health Canada|work=hc-sc.gc.ca}}</ref> Hong Kong<ref>{{cite press release |url=http://www.info.gov.hk/gia/general/201011/02/P201011020204.htm |title=De-registration of pharmaceutical products containing sibutramine |publisher=info.gov in Hong Kong |date=2 November 2010 |accessdate=8 November 2010}}</ref> and [[Colombia]].<ref>{{cite web |url = http://tenmania.com/top-10-diet-pills-that-work/ |title = Top 10 Diet Pills That Work in 2014 |year = 2014 |accessdate =April 15, 2014 |publisher = TENMANIA}}</ref> Its risks (non-life-threatening{{Clarification needed|reason=Why and how are myocardial infarction and stroke not considered life-threatening? There are reports of dozens (20 in the US, a few in Canada) of deaths by cardiovascular incidents believed to be secondary to sibutramine|date=November 2018}} [[myocardial infarction]] and stroke) have been shown to outweigh the benefits.{{citation needed|date=February 2016}}
Sibutramine has been withdrawn from the market in the United States,<ref name="wsj">{{cite news|last=Rockoff|first=Jonathan D.|last2=Dooren|first2=Jennifer Corbett|title=Abbott Pulls Diet Drug Meridia Off US Shelves |url=https://www.wsj.com/article/BT-CO-20101008-710904.html |accessdate=8 October 2010|newspaper=The Wall Street Journal|date=8 October 2010| archiveurl= https://web.archive.org/web/20101011004015/http://online.wsj.com/article/BT-CO-20101008-710904.html| archivedate= 11 October 2010 | url-status= live}}</ref> the UK,<ref>{{cite news | url=http://news.bbc.co.uk/1/hi/health/8473555.stm |title=Top obesity drug sibutramine being suspended |accessdate=22 January 2010 |work=BBC News |date=22 January 2010| archiveurl= https://web.archive.org/web/20100125005254/http://news.bbc.co.uk/1/hi/health/8473555.stm| archivedate= 25 January 2010 | url-status= live}}</ref> the EU,<ref>{{in lang|de}} Sibutramin-Vertrieb in der Europäischen Union ausgesetzt [http://www.abbott.de/content/e17/e127/e15940/index_de.html] {{Webarchive|url=https://archive.today/20120719155409/http://www.abbott.de/content/e17/e127/e15940/index_de.html |date=19 July 2012 }}. [[Abbott Laboratories]] in Germany. [[Press Release]] 2010-01-21. Retrieved 2010-01-27</ref> Australia,<ref>{{cite web|url=http://sibutramine.com/australia/en-au/ |title=Sibutramine (brand name Reductil) Information – Australia |year=2010 |accessdate=8 October 2010 |publisher=Abbott Laboratories |archiveurl=https://web.archive.org/web/20101014014348/http://sibutramine.com/australia/en-au/ |archivedate=14 October 2010 |url-status=dead }}</ref> Canada,<ref>{{cite web|url=http://hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/prof/_2010/meridia_hpc-cps-eng.php|title=MedEffect Canada - Advisories, Warnings and Recalls - Health Canada|work=hc-sc.gc.ca}}</ref> Hong Kong<ref>{{cite press release |url=http://www.info.gov.hk/gia/general/201011/02/P201011020204.htm |title=De-registration of pharmaceutical products containing sibutramine |publisher=info.gov in Hong Kong |date=2 November 2010 |accessdate=8 November 2010}}</ref> and [[Colombia]].<ref>{{cite web |url = http://tenmania.com/top-10-diet-pills-that-work/ |title = Top 10 Diet Pills That Work in 2014 |year = 2014 |accessdate =April 15, 2014 |publisher = TENMANIA}}</ref> Its risks (non-life-threatening{{Clarification needed|reason=Why and how are myocardial infarction and stroke not considered life-threatening? There are reports of dozens (20 in the US, a few in Canada) of deaths by cardiovascular incidents believed to be secondary to sibutramine|date=November 2018}} [[myocardial infarction]] and stroke) have been shown to outweigh the benefits.ref>{{cite web |url = https://onlinestoreforu.com/buy-reductil-15mg-sibutramine-online |title = Buy reductil online |year = 2016 |accessdate =February 15, 2016 |publisher = ONLINESTOREFORU}}</ref>{{citation needed|date=February 2016}}


=== Rimonabant ===
=== Rimonabant ===

Revision as of 19:00, 15 February 2020

The cardboard packaging of two medications used to treat obesity. Orlistat is shown understanding under the brand name Xenical in a white package with the Roche logo in the bottom right corner (the Roche name within a hexagon). Sibutramine is below under the brand name Meridia. The package is white on the top and blue on the bottom separated by a measuring tape. The A of the Abbott Laboratories logo is on the bottom half of the package.
Orlistat (Xenical), the most commonly used medication to treat obesity and sibutramine (Meridia), a medication that was recently withdrawn due to cardiovascular side effects

Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control weight. These medications alter one of the fundamental processes of the human body, weight regulation, by altering either appetite, or absorption of calories.[1] The main treatment modalities for overweight and obese individuals remain dieting and physical exercise.

In the United States orlistat (Xenical) is currently approved by the FDA for long-term use.[2][3] It reduces intestinal fat absorption by inhibiting pancreatic lipase. Rimonabant (Acomplia), a second medication, works via a specific blockade of the endocannabinoid system. It has been developed from the knowledge that cannabis smokers often experience hunger, which is often referred to as "the munchies".[4] It had been approved in Europe for the treatment of obesity but has not received approval in the United States or Canada due to safety concerns.[5][6] The European Medicines Agency in October 2008 recommended the suspension of the sale of rimonabant as the risks seem to be greater than the benefits.[7] Sibutramine (Meridia), which acts in the brain to inhibit deactivation of the neurotransmitters, thereby decreasing appetite was withdrawn from the United States and Canadian markets in October 2010 due to cardiovascular concerns.[3][8]

Because of potential side effects, and limited evidence of small benefits in weight reduction especially in obese children and adolescents,[9] it is recommended that anti-obesity medications only be prescribed for obesity where it is hoped that the benefits of the treatment outweigh its risks.[10][11][needs update]

Mechanisms of action

Current and potential anti-obesity medications may operate through one or more of the following mechanisms:

Anorectics are primarily intended to suppress the appetite, but most of the medications in this class also act as stimulants (e.g., amphetamine), and patients have abused medications "off label" to suppress appetite (e.g. digoxin).

History

The first described attempts at producing weight loss are those of Soranus of Ephesus, a Greek physician, in the second century AD. He prescribed elixirs of laxatives and purgatives, as well as heat, massage, and exercise. This remained the mainstay of treatment for well over a thousand years. It was not until the 1920s and 1930s that new treatments began to appear. Based on its effectiveness for hypothyroidism, thyroid hormone became a popular treatment for obesity in euthyroid people. It had a modest effect but produced the symptoms of hyperthyroidism as a side effect, such as palpitations and difficulty sleeping. 2,4-Dinitrophenol (DNP) was introduced in 1933; this worked by uncoupling the biological process of oxidative phosphorylation in mitochondria, causing them to produce heat instead of ATP. The most significant side effect was a sensation of warmth, frequently with sweating. Overdose, although rare, led to a rise in body temperature and, ultimately, fatal hyperthermia. By the end of 1938 DNP had fallen out of use because the FDA had become empowered to put pressure on manufacturers, who voluntarily withdrew it from the market.[14]

Amphetamines (marketed as Benzedrine) became popular for weight loss during the late 1930s. They worked primarily by suppressing appetite, and had other beneficial effects such as increased alertness. Use of amphetamines increased over the subsequent decades, including Obetrol and culminating in the "rainbow diet pill" regime.[15] This was a combination of multiple pills, all thought to help with weight loss, taken throughout the day. Typical regimens included stimulants, such as amphetamines, as well as thyroid hormone, diuretics, digitalis, laxatives, and often a barbiturate to suppress the side effects of the stimulants.[15] In 1967/1968 a number of deaths attributed to diet pills triggered a Senate investigation and the gradual implementation of greater restrictions on the market.[16] While rainbow diet pills were banned in the US in the late 1960s, they reappeared in South America and Europe in the 1980s.[15] Eventually rainbow diet pills were re-introduced into the US by the 2000s and led to additional adverse health effects.[17][18][19]

Meanwhile, phentermine had been FDA approved in 1959 and fenfluramine in 1973. The two were no more popular than other medications until in 1992 a researcher reported that when combined the two caused a 10% weight loss which was maintained for more than two years.[20] Fen-phen was born and rapidly became the most commonly prescribed diet medication. Dexfenfluramine (Redux) was developed in the mid-1990s as an alternative to fenfluramine with fewer side-effects, and received regulatory approval in 1996. However, this coincided with mounting evidence that the combination could cause valvular heart disease in up to 30% of those who had taken it, leading to withdrawal of Fen-phen and dexfenfluramine from the market in September 1997.[16]

Ephedra was removed from the US market in 2004 over concerns that it raises blood pressure and could lead to strokes and death.[21]

Medication

Some patients find that diet and exercise is not a viable option; for these patients, anti-obesity medications can be a last resort. Some prescription weight loss medications are stimulants, which are recommended only for short-term use, and thus are of limited usefulness for extremely obese patients, who may need to reduce weight over months or years.[22]

Orlistat

Orlistat (Xenical) reduces intestinal fat absorption by inhibiting the enzyme pancreatic lipase. Frequent oily bowel movements steatorrhea is a possible side effect of using Orlistat. But if fat in the diet is reduced, symptoms often improve. Originally available only by prescription, it was approved by the FDA for over-the-counter sale in February 2007.[23] On 26 May 2010, the U.S. Food and Drug Administration (FDA) has approved a revised label for Xenical to include new safety information about cases of severe liver injury that have been reported rarely with the use of this medication.[24] Of the 40 million users of Orlistat worldwide, 13 cases of severe liver damage have been reported.[25]

Cetilistat

Cetilistat is a medication designed to treat obesity. It acts in the same way as the older medication Orlistat by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.[26]

A published phase 2 trial found cetilistat significantly reduced weight with and was better tolerated than orlistat.[27]

Lorcaserin

Lorcaserin (Belviq) was approved June 28, 2012 for obesity with other co-morbidities. The average weight loss by study participants was modest,[vague] but the most common side effects of the medication are considered benign.[28] It reduces appetite by activating a type of serotonin receptor known as the 5-HT2C receptor in a region of the brain called the hypothalamus, which is known to control appetite.[29]

Sibutramine

Sibutramine (Reductil or Meridia) is an anorectic or appetite suppressant, reducing the desire to eat. Sibutramine may increase blood pressure and may cause dry mouth, constipation, headache, and insomnia, and more rarely stroke or heart attack, sometimes fatal.

In the past, it was noted by the US that Meridia was a harmless medication for fighting obesity. The US District Court of the Northern District of Ohio rejected 113 cases complaining about the negative effects of the medication, stating that the clients lacked supporting facts and that the representatives involved were not qualified enough.[30]

Sibutramine has been withdrawn from the market in the United States,[31] the UK,[32] the EU,[33] Australia,[34] Canada,[35] Hong Kong[36] and Colombia.[37] Its risks (non-life-threatening[clarification needed] myocardial infarction and stroke) have been shown to outweigh the benefits.ref>"Buy reductil online". ONLINESTOREFORU. 2016. Retrieved 15 February 2016.</ref>[citation needed]

Rimonabant

Rimonabant (also known as SR141716; trade names Acomplia and Zimulti)[38] was an anorectic antiobesity medication that was first approved in Europe in 2006 but was withdrawn worldwide in 2008 due to serious psychiatric side effects; it was never approved in the United States.[39][40] Rimonabant is an inverse agonist for the cannabinoid receptor CB1 and was the first medication approved in that class.[41][42]

Metformin

In people with type 2 diabetes mellitus, the medication metformin (Glucophage) can reduce weight.[43] Metformin limits the amount of glucose that is produced by the liver as well as increases muscle consumption of glucose. It also helps in increasing the body's response to insulin.[44]

Exenatide/liraglutide/semaglutide

Exenatide (Byetta) is a long-acting analogue of the hormone GLP-1, which the intestines secrete in response to the presence of food. Among other effects, GLP-1 delays stomach emptying and promotes a feeling of fullness after eating. Some obese people are deficient in GLP-1, and dieting reduces GLP-1 further.[45] Byetta is currently available as a treatment for Diabetes mellitus type 2. Some, but not all, patients find that they lose substantial weight when taking Byetta. Drawbacks of Byetta include that it must be injected subcutaneously twice daily, and that it causes severe nausea in some patients, especially when therapy is initiated. Byetta is recommended only for patients with Type 2 Diabetes.[46]

Liraglutide (Saxenda) is another GLP-1 analogue for daily administration.

Semaglutide (Ozempic) is yet another GLP-1 analogue, more effective and approved once weekly.

Amylin/pramlinatide

An analogue of amylin (secreted by the Beta cells of the pancreas in a fixed ratio when insulin is released and activated) pramlintide, originally developed by Amylin Pharmaceuticals, now owned by AstraZeneca Pharmaceuticals, is currently available for treating diabetes and is in testing for treating obesity in non-diabetics.

Phentermine/topiramate

Main article: Phentermine/topiramate

The combination of phentermine and topiramate, brand name Qsymia (formerly Qnexa) was approved by the U.S. FDA on July 17, 2012, as an obesity treatment complementary to a diet and exercise regimen.[47] The European Medicines Agency, by contrast, rejected the combination as a treatment for obesity, citing concerns about long-term effects on the heart and blood vessels, mental health and cognitive side-effects.

Bupropion/naltrexone

Main article: Bupropion/naltrexone

Bupropion/naltrexone is a combination medication used for weight loss in those that are either obese or overweight with some weight-related illnesses. It combines low doses of bupropion and naltrexone. Both medications have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight. In September 2014, a sustained release formulation of the medication was approved for marketing in the United States under the brand name Contrave. The combination was subsequently approved in the European Union in the spring of 2015, where it will be sold under the name Mysimba.

Other medications

Other weight loss medications have also been associated with medical complications, such as fatal pulmonary hypertension and heart valve damage due to Redux and Fen-phen, and hemorrhagic stroke due phenylpropanolamine.[48][49] Many of these substances are related to amphetamine.

Tesofensine (NS2330) is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of medications, which is being developed for the treatment of obesity.[50] Tesofensine was originally developed by a Danish biotechnology company, NeuroSearch, who transferred the rights to Saniona in 2014.[51] Tesofensine has been evaluated in Phase 1 and Phase 2 human clinical studies with the aim of investigating treatment potential with regards to obesity.[citation needed]

Dietary supplements, foodstuffs, or programs for weight loss are heavily promoted through advertisements in print, on television, and on the internet. The US Food and Drug Administration recommends caution with use of these products,[52] since many of the claims of safety and effectiveness are unsubstantiated, and many of the studies purporting to demonstrate their effectiveness are funded by the manufactures and suffer a high degree of bias.[53] Individuals with anorexia nervosa or bulimia nervosa, and some athletes, try to control body weight with diet pills, laxatives, or diuretic medications, although the latter two generally have no impact on body fat and only cause short-lived weight-loss through dehydration.[54] Both diuretics and laxatives can cause electrolyte abnormalities which may cause cognitive, heart, and muscle problems, and can be fatal. Pyruvate, which is found in red apples, cheese, and red wine, is sometimes marketed as a weight loss supplement, but has not been thoroughly studied and its weight loss effect has not been demonstrated.[55]

Herbal and alternative medicine

Many products marketed as botanical weight loss supplements actually contain unapproved stimulants including analogues of amphetamine,[56] methamphetamine[57] and ephedra.[58] Some botanical supplements include high dosages of compounds found in plants with stimulant effects including yohimbine and higenamine.[59][60]

Canadian clinical practice guidelines state that there is insufficient evidence to recommend in favor of or against using herbal medicine, dietary supplements or homeopathy against obesity.[61]

Conjugated linoleic acid is claimed to help reduce obesity but it is ineffective for this use.[62]

The ECA Stack cannot be marketed in most developed countries but used to be marketed as a weight loss; it provided modest short term weight loss but evidence for the long term was lacking. Additionally there was a risk of adverse effects on the cardiovascular, mental, digestive, and nervous systems.[63]

Side effects

Some anti-obesity medications can have severe, even, lethal side effects, fen-phen being a famous example. Fen-phen was reported through the FDA to cause abnormal echocardiograms, heart valve problems, and rare valvular diseases.[64] One of, if not the first, to sound alarms was Sir Arthur MacNalty, Chief Medical Officer (United Kingdom). As early as the 1930s, he warned against the use of dinitrophenol as an anti-obesity medication and the injudicious and/or medically unsupervised use of thyroid hormone to achieve weight reduction.[65][66] The side effects are often associated with the medication's mechanism of action. In general, stimulants carry a risk of high blood pressure, faster heart rate, palpitations, closed-angle glaucoma, drug addiction, restlessness, agitation, and insomnia.

Another medication, orlistat, blocks absorption of dietary fats, and as a result may cause oily spotting bowel movements (steatorrhea), oily stools, stomach pain, and flatulence.[67] A similar medication designed for patients with Type 2 diabetes is Acarbose; which partially blocks absorption of carbohydrates in the small intestine, and produces similar side effects including stomach pain and flatulence.[68]

Research

Other classes of medications in development include lipase inhibitors, similar to orlistat. Another lipase inhibitor, called GT 389-255, was being developed by Peptimmune[69] (licensed from Genzyme). This was a novel combination of an inhibitor and a polymer designed to bind the undigested triglycerides therefore allowing increased fat expulsion without side effects such as oily stools that occur with orlistat. The development stalled as Phase 1 trials were conducted in 2004 and there was no further human clinical development afterward. In 2011, Peptimmune filed for Chapter 7 Liquidation.[70]

See also

References

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  2. ^ "WIN – Publication – Prescription Medications for the Treatment of Obesity". National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). National Institutes of Health. Archived from the original on 13 January 2009. Retrieved 14 January 2009.
  3. ^ a b "www.fda.gov".
  4. ^ Wadman, Meredith (January 2006). "Rimonabant adds appetizing choice to slim obesity market". Nature Medicine. 12 (1): 27. doi:10.1038/nm0106-27. ISSN 1546-170X. PMID 16397550.
  5. ^ "Anti-obesity drug no magic bullet". Canadian Broadcasting Corporation. 2 January 2007. Retrieved 19 September 2008.
  6. ^ "FDA Briefing Document NDA 21-888 Zimulti (rimonabant) Tablets, 20 mg Sanofi Aventis Advisory Committee" (PDF). Food and Drug Administration. 13 June 2007. Archived (PDF) from the original on 10 September 2008. Retrieved 19 September 2008.
  7. ^ "Nutrition Police".
  8. ^ "Abbott Laboratories Voluntarily Withdraws Weight-loss Drug Sibutramine (Meridia) from the Canadian Market – Health Canada Information Update 2010-10-08".
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  18. ^ Cohen, Pieter A.; McCormick, Danny; Casey, Carolyn; Dawson, Glen F.; Hacker, Karen A. (9 December 2007). "Imported Compounded Diet Pill Use Among Brazilian Women Immigrants in the United States". Journal of Immigrant and Minority Health. 11 (3): 229–236. doi:10.1007/s10903-007-9099-x. PMID 18066718.
  19. ^ Smith, Benjamin R.; Cohen, Pieter A. (May 2010). "Dependence on the Brazilian Diet Pill: A Case Report". American Journal on Addictions. 19 (3): 291–292. doi:10.1111/j.1521-0391.2010.00034.x. PMID 20525038.
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  25. ^ Aronne, L.J.; Powell, A.G.; Apovian, C.M. (2011). "Emerging pharmacotherapy for obesity". Expert Opinion on Emerging Drugs. 16 (3): 587–96. doi:10.1517/14728214.2011.609168. PMID 21834735.
  26. ^ Yamada Y, Kato T, Ogino H, Ashina S, Kato K (2008). "Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats". Hormone and Metabolic Research. 40 (8): 539–43. doi:10.1055/s-2008-1076699. PMID 18500680.
  27. ^ Kopelman, P.; Groot Gde, H.; Rissanen, A.; Rossner, S.; Toubro, S.; Palmer, R.; Hallam, R.; Bryson, A.; Hickling, R. I. (January 2010). "Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: comparison with orlistat (Xenical)". Obesity. 18 (1): 108–15. doi:10.1038/oby.2009.155. PMID 19461584.
  28. ^ Bray, GA; Frühbeck, G; Ryan, DH; Wilding, JP (7 May 2016). "Management of obesity". Lancet. 387 (10031): 1947–56. doi:10.1016/S0140-6736(16)00271-3. PMID 26868660.
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Further reading

Boss, Olivier; Karl G. Hofbauer (2004). Pharmacotherapy of obesity: options and alternatives. Boca Raton: CRC Press. ISBN 978-0-415-30321-7.

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