Jump to content

Leland H. Hartwell: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
→Cite journal, patent, LCCN, VIAF
Too many inaccuracies
Line 16: Line 16:
}}
}}
'''Leland Harrison (Lee) Hartwell''' (born October 30, 1939, in [[Los Angeles, California|Los Angeles]], [[California]]) is former president and director of the [[Fred Hutchinson Cancer Research Center]] in [[Seattle, Washington]]. He shared the 2001 [[Nobel Prize in Physiology or Medicine]] with [[Paul Nurse]] and [[Tim Hunt|R. Timothy Hunt]], for their discoveries of protein molecules that control the division (duplication) of cells.<ref name="illpres">[http://www.nobelprize.org/nobel_prizes/medicine/laureates/2001/illpres/index.html The Nobel Prize in Physiology or Medicine 2001] Illustrated Lecture</ref>
'''Leland Harrison (Lee) Hartwell''' (born October 30, 1939, in [[Los Angeles, California|Los Angeles]], [[California]]) is former president and director of the [[Fred Hutchinson Cancer Research Center]] in [[Seattle, Washington]]. He shared the 2001 [[Nobel Prize in Physiology or Medicine]] with [[Paul Nurse]] and [[Tim Hunt|R. Timothy Hunt]], for their discoveries of protein molecules that control the division (duplication) of cells.<ref name="illpres">[http://www.nobelprize.org/nobel_prizes/medicine/laureates/2001/illpres/index.html The Nobel Prize in Physiology or Medicine 2001] Illustrated Lecture</ref>

When cells with nuclei divide, they divide in phases called G1 (growth), S (synthesis), G2 (growth), and M (mitosis). Nurse, Hartwell and Hunt together discovered two proteins, cyclin and CDK (cyclin dependent kinase), that control the transition from one stage to another. These proteins are called checkpoints, because they check whether the cell has divided properly. If the cell doesn't divide correctly, other proteins will attempt to repair it, and if unsuccessful, they will destroy the cell. If a cell divides incorrectly and survives, it can cause cancer and other serious diseases.<ref name="illpres"/>


Working in yeast, Hartwell identified the fundamental role of checkpoints in cell cycle control, and CDC genes such as CDC28, which controls the start of the cycle -- the progression through G1.<ref name="illpres"/>
Working in yeast, Hartwell identified the fundamental role of checkpoints in cell cycle control, and CDC genes such as CDC28, which controls the start of the cycle -- the progression through G1.<ref name="illpres"/>

Revision as of 16:54, 11 December 2012

Leland H. Hartwell
Born (1939-10-30) 30 October 1939 (age 85)
Los Angeles, California, U.S.
Alma materCalifornia Institute of Technology, Massachusetts Institute of Technology
Known forCell cycle regulation
AwardsAlbert Lasker Award (1988) Nobel Prize in Physiology or Medicine (2001)
Scientific career
FieldsBiology
InstitutionsFred Hutchinson Cancer Research Center
Arizona State University
Biodesign Institute Amrita Vishwa Vidyapeetham

Leland Harrison (Lee) Hartwell (born October 30, 1939, in Los Angeles, California) is former president and director of the Fred Hutchinson Cancer Research Center in Seattle, Washington. He shared the 2001 Nobel Prize in Physiology or Medicine with Paul Nurse and R. Timothy Hunt, for their discoveries of protein molecules that control the division (duplication) of cells.[1]

Working in yeast, Hartwell identified the fundamental role of checkpoints in cell cycle control, and CDC genes such as CDC28, which controls the start of the cycle -- the progression through G1.[1]

Education

Hartwell received his bachelor's degree from the California Institute of Technology in 1961. In 1964, he received his PhD in biology from the Massachusetts Institute of Technology. From 1965 to 1968, he worked at the University of California, Irvine as a professor. He moved to the University of Washington in 1968. In a series of experiments from 1970 to 1971, Hartwell discovered the cell division cycle (CDC) genes in baker's yeast (Saccharomyces cerevisiae). These genes regulate the cell cycle and mutations in the genes are involved in some types of cancer.

Awards and honors

In addition to the Nobel Prize, Hartwell has received many awards and honors including the Louisa Gross Horwitz Prize from Columbia University in 1995. He became a member of the National Academy of Sciences in 1987. In 1996, Hartwell joined the faculty of Fred Hutchinson Cancer Research Center and in 1997 became its president and director.

In 1998 he received the Albert Lasker Award for Basic Medical Research. On July 9, 2003, Washington Governor Gary Locke awarded the Medal of Merit, the state’s highest honor, to Hartwell. He is also a recipient of the Komen Brinker Award for Scientific Distinction.

Other positions

Hartwell is the Chairman of the Scientific Advisory Board at the Canary Foundation, a non-profit organization dedicated to developing new technologies for the early detection of cancer. He is also a founding co-chair of the Pacific Health Summit, and a member of its Executive Committee.[2] In September 2009, it was announced that Hartwell will join the faculty of Arizona State University as the Virginia G. Piper Chair of Personalized Medicine and co-director of the Biodesign Institute's new Center for Sustainable Health with Dr. Michael Birt.[3][4]

References

  1. ^ a b The Nobel Prize in Physiology or Medicine 2001 Illustrated Lecture
  2. ^ Pacific Health Summit, About the Summit, 2011
  3. ^ Hartwell to join ASU faculty ASU News
  4. ^ Arizona State University and Virginia G. Piper Charitable Trust tap Nobel Prize winner Dr. Lee Hartwell to lead major health initiative Biodesign Institute News
  • Hartwell LH, Culotti J, Reid B (1970). "Genetic control of the cell-division cycle in yeast. I. Detection of mutants". Proc. Natl. Acad. Sci. U.S.A. 66 (2): 352–9. PMC 283051. PMID 5271168. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  • Les Prix Nobel. 2002. The Nobel Prizes 2001, Editor Tore Frängsmyr. Nobel Foundation: Stockholm.

http://news.amrita.edu/news/2011/10/06/nobel-prize-winner-is-adjunct-faculty-at-amrita/

Template:Persondata

Retrieved from "https://en.wikipedia.org/w/index.php?title=Leland_H._Hartwell&oldid=527558218"