Abafungin: Difference between revisions

Abafungin
Clinical data
Trade names	Abasol
Routes of; administration	Topical (cream)
ATC code	none;
Identifiers
	IUPAC name N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine;
CAS Number	129639-79-8;
PubChem CID	159326;
ChemSpider	140124 ;
UNII	11DI31LWXF;
ChEBI	CHEBI:76005;
CompTox Dashboard (EPA)	DTXSID60869776 ;
ECHA InfoCard	100.125.129
Chemical and physical data
Formula	C21H22N4OS
Molar mass	378.491 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=C(C=C1)OC2=CC=CC=C2C3=CSC(=N3)NC4=NCCCN4)C;
	InChI InChI=1S/C21H22N4OS/c1-14-8-9-18(15(2)12-14)26-19-7-4-3-6-16(19)17-13-27-21(24-17)25-20-22-10-5-11-23-20/h3-4,6-9,12-13H,5,10-11H2,1-2H3,(H2,22,23,24,25) ; Key:TYBHXIFFPVFXQW-UHFFFAOYSA-N ;
	(verify)

Content deleted Content added

Inline

Revision as of 06:34, 2 October 2016

Abafungin (INN) is a broad-spectrum antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.

Abasol is a topical cream formulation of abafungin by York Pharma.^[1]

Unlike imidazole- and triazole-class antifungals, abafungin directly impairs the fungal cell membrane.^[2]

In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.^[3]

Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity.^[4]

^ York Pharma: Regulatory Update – Abasol Archived (Date missing) at yorkpharma.com (Error: unknown archive URL)
^ Borelli C1, Schaller M, Niewerth M, Nocker K, Baasner B, Berg D, Tiemann R, Tietjen K, Fugmann B, Lang-Fugmann S, Korting HC. "Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi". Chemotherapy. 2008;54(4):245-59
^ Borelli C1, Schaller M, Niewerth M, Nocker K, Baasner B, Berg D, Tiemann R, Tietjen K, Fugmann B, Lang-Fugmann S, Korting HC. "Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi". Chemotherapy. 2008;54(4):245-59
^ Ginter-Hanselmayer, Gabriele (March 2009), Arbeitsunterlagen zur 42. wissenschaftlichen Fortbildungsveranstaltung für Apothekerinnen und Apotheker: Infektionskrankheiten, Österreichische Apothekerkammer, p. 103

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.

@@ Line 55: / Line 55: @@
 '''Abafungin''' ([[International Nonproprietary Name|INN]]) is a broad-spectrum [[antifungal agent]] with a novel mechanism of action for the treatment of [[dermatomycoses]].
-'''Abasol''' is a topical cream formulation of abafungin by [[York Pharma]].<ref>[http://www.yorkpharma.com/media/YRK-Update_Abasol_061002-FN.pdf York Pharma: Regulatory Update – Abasol]</ref>
+'''Abasol''' is a topical cream formulation of abafungin by [[York Pharma]].<ref>[http://www.yorkpharma.com/media/YRK-Update_Abasol_061002-FN.pdf York Pharma: Regulatory Update – Abasol] {{wayback|url=http://www.yorkpharma.com/media/YRK-Update_Abasol_061002-FN.pdf |date=20070927102715 }}</ref>
 ==Mechanism of action==