Cefuroxime axetil: Difference between revisions
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'''Cefuroxime axetil''' is a second generation oral [[cephalosporin]] [[antibiotic]]. It was discovered by Glaxo now [[GlaxoSmithKline]] and introduced in 1987 as '''Zinnat'''.<ref>{{cite web | url = http://www.gsk.com/about/history.htm | title = Our history - About GSK | publisher = GlaxoSmithKline}}</ref> It was approved by FDA on Dec 28, 1987.<ref>http://www.drugs.com/monograph/cefuroxime-axetil.html</ref> It is available by [[GlaxoSmithKline|GSK]] as Ceftin in US<ref>https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductsByName#C</ref> and Ceftum in India.<ref>{{Cite web | url = http://www.gsk-india.com/product-antiinfective.html | title = Our products | publisher = GlaxoSmithKline}}</ref> |
'''Cefuroxime axetil''' is a second generation oral [[cephalosporin]] [[antibiotic]]. It was discovered by Glaxo now [[GlaxoSmithKline]] and introduced in 1987 as '''Zinnat'''.<ref>{{cite web | url = http://www.gsk.com/about/history.htm | title = Our history - About GSK | publisher = GlaxoSmithKline | deadurl = yes | archiveurl = https://web.archive.org/web/20110514143603/http://www.gsk.com/about/history.htm | archivedate = 2011-05-14 | df = }}</ref> It was approved by FDA on Dec 28, 1987.<ref>http://www.drugs.com/monograph/cefuroxime-axetil.html</ref> It is available by [[GlaxoSmithKline|GSK]] as Ceftin in US<ref>https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductsByName#C</ref> and Ceftum in India.<ref>{{Cite web | url = http://www.gsk-india.com/product-antiinfective.html | title = Our products | publisher = GlaxoSmithKline}}</ref> |
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It is an acetoxyethyl ester [[prodrug]] of [[cefuroxime]] which is effective orally.<ref>{{cite book | title = Drug Discovery: A History | author = Walter Sneader | publisher = John Wiley, Chichester, UK | isbn = 0-471-89979-8 | page = | url = https://books.google.com/books?id=Cb6BOkj9fK4C&pg=PA326 }}</ref> The activity depends on ''[[in vivo]]'' [[hydrolysis]] and release of cefuroxime tablets. |
It is an acetoxyethyl ester [[prodrug]] of [[cefuroxime]] which is effective orally.<ref>{{cite book | title = Drug Discovery: A History | author = Walter Sneader | publisher = John Wiley, Chichester, UK | isbn = 0-471-89979-8 | page = | url = https://books.google.com/books?id=Cb6BOkj9fK4C&pg=PA326 }}</ref> The activity depends on ''[[in vivo]]'' [[hydrolysis]] and release of cefuroxime tablets. |
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Revision as of 17:11, 1 August 2017
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| Clinical data | |
|---|---|
| Trade names | Zinnat, Ceftin, Ceftum |
| Other names | Cefuroxime 1-acetoxyethyl ester |
| Routes of administration | Oral |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | well absorbed |
| Metabolism | Cefuroxime is not metabolized, Axetil is metabolized to acetaldehyde and acetic acid. |
| Excretion | Urine |
| Identifiers | |
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| PubChem CID | |
| ChemSpider | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.166.374 |
| Chemical and physical data | |
| Formula | C20H22N4O10S |
| Molar mass | 510.475 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Cefuroxime axetil is a second generation oral cephalosporin antibiotic. It was discovered by Glaxo now GlaxoSmithKline and introduced in 1987 as Zinnat.[1] It was approved by FDA on Dec 28, 1987.[2] It is available by GSK as Ceftin in US[3] and Ceftum in India.[4]
It is an acetoxyethyl ester prodrug of cefuroxime which is effective orally.[5] The activity depends on in vivo hydrolysis and release of cefuroxime tablets.
See also
References
- ^ "Our history - About GSK". GlaxoSmithKline. Archived from the original on 2011-05-14.
{{cite web}}: Unknown parameter|deadurl=ignored (|url-status=suggested) (help) - ^ http://www.drugs.com/monograph/cefuroxime-axetil.html
- ^ https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductsByName#C
- ^ "Our products". GlaxoSmithKline.
- ^ Walter Sneader. Drug Discovery: A History. John Wiley, Chichester, UK. ISBN 0-471-89979-8.