The Cleveland Indians open their season with three consecutive extra innings games, amassing 41 total innings.
After ten innings, the contest between the Philadelphia Phillies and New York Giants at the Baker Bowl is called a 4-4 tie. The Phillies tie an NL record by turning six double plays, with Phillies shortstopBlondy Ryan tying the individual mark by being part of five of the double plays.
May 8 – In the first game of a double header with the Philadelphia Phillies, Cincinnati Reds catcherErnie Lombardi ties a Major League record by hitting four consecutive doubles en route to a 15-4 victory. Lombardi logs just one at-bat in the second game, and gets a single.
May 25 – Babe Ruth of goes 4-for-4 with three home runs and six runs batted in. It is the last multi-homer game of Ruth's career, with the final home run, the 714th of his career, being the first ball ever hit to clear the roof at Forbes Field in Pittsburgh.
May 30 – Babe Ruth ends his playing career with the Boston Braves.
July 22 – With a 4-2 victory over the Cincinnati Reds, the Boston Braves end a fifteen-game losing streak.
July 23 – With first place in the American League on the line, the Detroit Tigers and New York Yankees split a double header. Detroit wins the following day, 4-0, to leave Detroit a half game up on the Yankees. They remain in first for the remainder of the season.
August 10 – The New York Yankees defeat the Philadelphia A's, 18-7. Right fielderGeorge Selkirk hits two home runs and drives in eight.
August 27 – In the first game of a double header at Comiskey Park with the Chicago White Sox, Lou Gehrig goes three-for-five with two RBIs and two runs scored to lead the Yankees to a 13-10 victory. In the second game, Gehrig is walked five times. Chicago wins that game, 4-3.
August 31 – Vern Kennedy pitches a no-hitter as the Chicago White Sox defeat the Cleveland Indians, 5–0. It is the first no-hitter in the American League since 1931, and the first ever at Chicago's Comiskey Park.
September 12 – The Philadelphia Athletics sweep a double header from the Chicago White Sox to end a thirteen-game losing streak.
September 27 – The first place Chicago Cubs sweep a double header with the St. Louis Cardinals that brings their winning streak to 27 games. The Cubs were in third place, 2.5 games back of the Cards, when the streak began.
October 2 – Schoolboy Rowe pitched effectively, however, his fielding error lead to two unearned runs in the first inning as the Chicago Cubs take game one of the 1935 World Series, 3-0.
October 3 – Hank Greenberg's two run home run caps off a four run first inning for the Tigers as Detroit takes game two of the World Series, 8-3. In the bottom of the seventh, Greenberg is hit by a pitch that ends his season.
October 4 – As part of a double switch, Freddie Lindstrom moves from centerfield to third base in the tenth inning of game three of the World Series. An inning later, he misplays Flea Clifton's ground ball to allow the Detroit Tigers to take the 6-5 victory.
October 5 – Gabby Hartnett hits a second-inning home run to put the Cubs on the board first, but the Tigers come back with two unanswered runs, and win 2-1.
November 26 – The National League assumes control of the bankrupt, Boston Braves franchise after several failed attempts to buy the last-place club. The league takes over only temporarily, until matters can be straightened out.
January 14 – Irv Young, 57, pitcher for the Beaneaters, Doves, WhiteSox and Pirates in six seasons from 1905–1911, a 20-game winner in his rookie season, who twice led the National League in starts, complete games and innings pitched.
January 29 – Ed Murphy, 58, pitcher for the 1898 Philadelphia Phillies and for the St. Louis Cardinals from 1901 to 1903.
March 11 – George Rooks, 71, backup outfielder for the Boston Beaneaters during the 1891 season.
March 15 – Ed Fuller, 65, pitcher for the 1886 Washington Nationals.
March 16 – Oscar Streit, 61, pitcher for the Boston Beaneaters in 1899 and the Cleveland Bronchos in 1902.
March 20 – Bill Holbert, 80, catcher for the Louisville Grays, Milwaukee Grays, Syracuse Stars, Troy Trojans, New York Metropolitans and Brooklyn Bridegrooms in 12 seasons spanning 1876–1888, who holds the major league record for career at-bats without a home run, failing to do so in 2,335 batting appearances.
March 23 – John Flynn, 51, first baseman who played from 1910 through 1912 with the Pittsburgh Pirates and Washington Senators, also a minor league manager.
March 31 – Steve Libby, 81, first baseman who played for the Buffalo Bisons of the National League for one game during the 1879 season, and eventually served as an umpire in the league.
May 3 – Ted Breitenstein, 65, pitcher for the Browns, Reds and Cardinals from 1891–1901, whose 160 victories were the most by a 19th-century left-hander, who also hurled two no-hitters, twice led the National League in complete games, and collected three 20-win seasons.
May 4 – Dory Dean, 82, pitcher for the 1876 Cincinnati Reds.
May 7 – Sid Farrar, 75, infielder for the Philadelphia Quakers/Athletics from 1883 to 1890.
May 16 – Pete Weckbecker, 70, catcher who played from 1889 to 1890 for the Indianapolis Hoosiers and Louisville Colonels.
May 16 – Mark McGrillis, 62, third baseman who played for the 1892 St. Louis Browns of the National League.
July 2 – Hank O'Day, 75, Hall of Fame umpire who officiated in the National League for 30 years between 1895 and 1927 and worked in ten World Series, previously a pitcher in the Players' League and a manager for the Reds and Cubs.
July 10 – Paul Hines, 83, outfielder/infielder and one of the top stars in the early days of baseball, who is given credit for 13 firsts in Major League history, including the first unassisted triple play and the first Triple Crown, also a .302 hitter in 20 seasons from 1872–1891, while amassing more hits than any other player in the National League over its first five seasons.
July 18 – Tom Ryder, 72, backup outfielder for the St. Louis Maroons of the Union Association during the 1884 season.
July 24 – Billy Crowell, 49, pitcher who played from 1887 to 1888 for the Cleveland Blues and Louisville Colonels.
July 26 – Bill Whitrock, 65, pitcher for the St. Louis Browns, Louisville Colonels, Cincinnati Reds and Philadelphia Phillies in part of four seasons spanning 1890–1896.
September 3 – Mike Ryan, 67, third baseman for the 1895 St. Louis Browns of the National League.
September 4 – Dan Cotter, 68, pitcher who played with the Buffalo Bisons of the Players' League in 1890.
September 10 – Pug Bennett, 61, second baseman who played from 1906 to 1907 for the St. Louis Cardinals.
September 12 – Ed Beecher, 75, outfielder who played with the Pittsburg Alleghenys, Washington Nationals, Buffalo Bisons, Washington Statesmen and Philadelphia Athletics in part of four seasons spanning 1897–1891.
September 15 – Joe Ardner, 77, second baseman who played for the Cleveland Blues in 1884 and the Cleveland Spiders in 1890.
September 17 – Len Koenecke, 31, Canadian outfielder who played for the New York Giants in 1932 and the Brooklyn Dodgers from 1934 to 1935.
September 21- Herm McFarland, 65, outfielder who played for the Louisville Colonels, Cincinnati Reds, Chicago White Sox, Baltimore Orioles and New York Highlanders in all or part of five seasons from 1896–1903.
September 21 – Henry Yaik, 71, catcher and outfielder who played with the Pittsburg Alleghenys in the 1888 season.
October 11 – George Pierce, 47, pitcher who played from 1912 through 1917 for the Chicago Cubs and St. Louis Cardinals.
October 11 – Chick Smith, 42, pitcher for the 1913 Cincinnati Reds.
October 12 – Ray Treadaway, 27, third baseman who played with the Washington Senators during the 1930 season.
October 19 – Walt Doan, 48, pitcher for the Cleveland Naps in 1909 and 1910.
October 22 – Tommy Tucker, 71, first baseman for the Baltimore Orioles, Boston Beaneaters, Washington Senators, Brooklyn Bridebrooms, St. Louis Browns, and Cleveland Spiders between 1887 and 1899, who led the American Association hitters in 1889 with a .372 average.
October 30 – Steve Brodie, 67, outfielder and a .303 career hitter for the Beaneaters, Browns, Orioles, Pirates and Giants during 11 seasons spanning 1890–1902.
November 6 – Billy Sunday, 72, popular outfielder in the National League during the 1880s, who became the most celebrated and influential American evangelist during the first two decades of the 20th century.
November 9 – Rex DeVogt, 47, backup catcher for the Boston Braves during the 1913 season.
November 13 – Frank Navin, 64, owner of the Detroit Tigers since 1908 who assembled the American League pennant-winning clubs of 1907, 1908, 1909 and 1934, as well as the 1935 World Series champion team.
November 17 – Carl Cashion, 44, pitcher for the Washington Senators from 1911 to 1914.
December 8 – Baldy Louden, 52, second baseman/shortstop for the New York Highlanders (1907), Detroit Tigers (1912–1913) and Cincinnati Reds (1920), who enjoyed his greatest success while playing with the Buffalo Buffeds/Blues of the Federal League, when he ranked among the top-ten in several offensive categories in the 1914 and 1915 seasons.
December 17 – Charlie Atherton, 62, third baseman for the 1899 Washington Senators of the National League.
December 21 – Cy Rigler, 53, National League umpire since 1906, who worked in ten World Series, the first All-Star game, and is regarded by creating arm signals for balls and strikes count.
December 28 – Jack Corcoran, 77, catcher for the 1884 Brooklyn Atlantics.
December 29 – Harley Payne, 67, pitcher who played from 1896 through 1899 for the Brooklyn Bridegrooms and the Pittsburgh Pirates.