May 1 – The Houston Astros, no-hit the day before by Jim Maloney of the Cincinnati Reds, answer back as Don Wilson pitches a 4-0 no-hitter, with 13 strikeouts over the Reds. Houston ties a National League record with just one assist. In Wilson's previous start against Cincinnati, on April 22, he gave up six runs in five innings in a 14-0 loss. The back-to-back no-hitters are only the second in Major League history, the feat having been accomplished just the year before by Gaylord Perry and Ray Washburn.
June 22 – The Cubs score four runs in the ninth inning to defeat the Montreal Expos 7-6 in the first game of a double-header at Wrigley Field. Jim Hickman hit a 2-run walk-off homer.
June 26 – Jim Hickman's home run in the 10th inning defeats the Pittsburgh Pirates 7-5 at Wrigley Field. On the spur of the moment Ron Santo leaped in the air and clicked his heels 3 times on the way to the clubhouse. The victory dance became a hit with euphoric Cub fans.
July 8 – With three runs in the 9th inning, the New York Mets beat the Chicago Cubs 4-3, cutting Chicago's lead in the National League East to four games. Chicago's Ron Santo rips into center fielder Don Young for two misplays in the outfield; Santo apologizes the next day for criticizing Young, who had left early and didn't take the team bus. Santo is later booed in his first game back at Wrigley Field.
July 30 – After losing the first game of a doubleheader with the Houston Astros 16-3, the New York Mets were down 7-0 in the third inning when Johnny Edwards hit a double to Cleon Jones in left field to make the score 8-0. Mets manager Gil Hodges emerged from the dugout, walked past Nolan Ryan on the mound, and walked all the way out to left field. A few minutes later, Hodges walked back to the dugout, with Jones a few paces behind him, and replaced Jones in left with Ron Swoboda. According to Jones, he pointed down to the water filled turf. Hodges then said that something must be wrong with Jones's ankle and pulled him for that reason (Jones was kept out of the line-up for the next two games, and used only as a pinch hitter in the two after that). Newspapers report that Jones was removed for failure to hustle, and Hodges decided to do so publicly to show that he would not tolerate lack of effort on his team, even from its star player.
August 5 – The Pittsburgh Pirates' Willie Stargell hits the first home run ever hit completely out of Dodger Stadium. Los Angeles pitcher Alan Foster surrenders the 506-foot blast—to date, the longest home run in Dodger Stadium history. (Stargell will hit another homer out of Dodger Stadium, off Andy Messersmith in 1973.) The mammoth home run comes in the seventh inning and breaks a 3-3 tie, a three-run home run by Andy Kosco having tied the game for the Dodgers in the bottom of the sixth; Pittsburgh scores seven more runs in the ninth inning and defeats Los Angeles 11-3.
Citing damage to his right shoulder, Don Drysdale retires from the Los Angeles Dodgers. He is the last player still playing for the Dodgers that had also played in Brooklyn.
August 14 – In the National League Eastern Division, the Chicago Cubs lead the St. Louis Cardinals by 8.5 games and the New York Mets by 9.5 games.
August 19 – At Wrigley Field, Ken Holtzman of the Chicago Cubsno-hits the Atlanta Braves 3-0 without striking out a single batter the entire game. Only one other pitcher in Major League history, Sad Sam Jones in 1923, has hurled a no-hitter without the benefit of a strikeout. Holtzman survives a scare in the seventh as Hank Aaron's fly ball to deep left field leading off the inning appears to be going over the wall for a home run; however, a stiff wind cuts into the ball and enables Billy Williams to catch it at the warning track. Aaron will ground out to Cubs' second baseman Glenn Beckert for the game's final out.
September 9 – During the Mets' 7-1 victory over the Chicago Cubs at Shea, a black cat jumps on the field and runs past Ron Santo in the on-deck circle.
September 10 – A loss by the Chicago Cubs, and a double header sweep by the New York Mets, gives the Mets their first ever lead of the National League East Division. The Mets will not relinquish their lead from this point, as the Cubs suffer through a legendary collapse.
September 24 – After 7 uninspired losing seasons, the New York Mets clinch the National League East Division title as Donn Clendenon hit 2 home runs in a 6-0 Mets win over Steve Carlton and the St. Louis Cardinals. The Mets have won 38 out of their 49 games dating from August 14. The Cubs will finish the season 8 games behind the Mets, and not win the division until exactly fifteen years from this day.
October 8 - After firing Dave Bristol as manager despite a 89-73 season, the Cincinnati Reds hire Sparky Anderson to replace him. Over the next seven seasons, Anderson, who will be making his Major League managerial debut in 1970, will guide the team known as the "Big Red Machine" to five National League West titles, four National League pennants, and back-to-back World Series titles in 1975 and 1976.
November 25 – Outfielder Lou Piniella, who hit .282 with 11 home runs and 68 RBI, is named American League Rookie of the Year over pitcher Mike Nagy (12-2, 3.11 ERA), outfielder Carlos May (.281, 18, 62) and pitcher Ken Tatum (7-2, 1.36).
January 6 – Hank Olmsted, 89, pitcher for the 1905 Boston Americans
January 23 – Al Bridwell, 85, shortstop whose apparent game-winning single for the New York Giants in a 1908 contest led to the controversial play in which baserunner Fred Merkle was eventually called out for not touching second base
February 19 – Doc White, 89, Chicago White Sox pitcher whose record of five consecutive shutouts was finally broken by Don Drysdale in 1968
March 14 – Heinie Zimmerman, 82, third baseman who won the NL triple crown in 1912 but was barred from baseball in 1919 for his role in fixing games
March 16 – William Bell, 71, All-Star pitcher of the Negro Leagues who posted the highest career winning percentage in black baseball
March 21 – Pinky Higgins, 59, third baseman who held the AL record for career games at that position, a 3-time All-Star and later manager of the Red Sox
April 4 – Les Wilson, 83, outfielder who played for the 1911 Boston Red Sox
April 7 – Si Rosenthal, 65, outfielder who played from 1925 to 1926 for the Boston Red Sox
April 19 – Rip Collins, 59, catcher for the Chicago Cubs and New York Yankees in the 1940s
May 1 – Gary Wilson, 90, second baseman for the 1902 Boston Americans
May 5 – Eddie Cicotte, 84, pitcher who won 208 games for the Tigers, Red Sox and White Sox, but was thrown out of baseball as one of the eight "Black Sox" involved in fixing the 1919 World Series; he was the first of the eight to come forward, confessing his involvement and testifying before the grand jury
May 17 – Pants Rowland, 90, manager of the 1917 World Series champion Chicago White Sox, later president of the Pacific Coast League from 1944 to 1954
May 20 – Lee Allen, 54, historian at the Baseball Hall of Fame since 1959, former sportswriter
May 25 – Jim Riley, 74, Canadian infielder for the St. Louis Browns and Washington Senators, who also is the only athlete in sports history to play both Major League Baseball and in the National Hockey League.
June 24 – John Perrin, 71, right fielder for 1921 Boston Red Sox; later a fullback/quarterback for the NFL Hartford Blues
July 8 – Bill Carrigan, 85, manager and backup catcher for the Boston Red Sox' world champions in 1915 and 1916
September 29 – Tommy Leach, 91, third baseman and center fielder, primarily for the Pittsburgh Pirates, who led the NL in runs twice and home runs once
September 30 – Jim Galvin, 62, played briefly for the 1930 Boston Red Sox
September 30 – Hank Thompson, 43, third baseman who was the third black player in MLB history and played on the 1954 New York Giants World Series championship team
October 2 – Gordon Cobbledick, 70, sportswriter for the Cleveland Plain Dealer from 1928 to 1964
October 9 – Don Hoak, 41, third baseman who played on 1955 Brooklyn Dodgers and 1960 Pittsburgh Pirates World Series championship teams.
November 1 – George Winn, 72, pitcher for the Boston Red Sox (1919) and Cleveland Indians (1922–23)
November 14 – Curt Roberts, 40, first black player in Pittsburgh Pirates history
November 15 – Billy Southworth, 76, manager who won World Series titles in 1942 and 1944 with the St. Louis Cardinals and the 1948 NL pennant with the Boston Braves, posting a .597 career winning percentage
November 30 – Eddie Eayrs, 79, outfielder/pitcher who played for the Pittsburgh Pirates, Boston Braves and Brooklyn Robins in the early 20th century
December 3 – Roy Wilson, 83, pitcher for the Chicago White Sox in the 1920s
December 7 – Lefty O'Doul, 72, left fielder who batted .349 in his career and won two batting titles after being converted from a pitcher; became the winningest manager in Pacific Coast League history, and earned additional fame as the "father" of professional baseball in Japan
December 11 – Ollie Fuhrman, 83, catcher who hit .333 for the Philadelphia Athletics in 1922.