Collagen, type XV, alpha 1

COL15A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N3F
Identifiers
Aliases	COL15A1, collagen type XV alpha 1 chain
External IDs	OMIM: 120325; MGI: 88449; HomoloGene: 1396; GeneCards: COL15A1; OMA:COL15A1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.33 Start 98,943,179 bp End 99,070,792 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 B1 Start 47,208,161 bp End 47,313,167 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta synovial joint cardia right ventricle pericardium superficial temporal artery saphenous vein vena cava pylorus synovial membrane Top expressed in ascending aorta aortic valve sciatic nerve white adipose tissue extraocular muscle uterus subcutaneous adipose tissue thoracic diaphragm esophagus lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function extracellular matrix structural constituent structural molecule activity extracellular matrix structural constituent conferring tensile strength Cellular component integral component of membrane basement membrane collagen endoplasmic reticulum lumen extracellular exosome collagen type XV trimer extracellular region extracellular matrix extracellular space collagen-containing extracellular matrix Biological process collagen catabolic process multicellular organism development cell differentiation angiogenesis signal transduction cell adhesion extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1306 12819 Ensembl ENSG00000204291 ENSMUSG00000028339 UniProt P39059 O35206 RefSeq (mRNA) NM_001855 NM_009928 RefSeq (protein) NP_001846 NP_034058 Location (UCSC) Chr 9: 98.94 – 99.07 Mb Chr 4: 47.21 – 47.31 Mb PubMed search
Wikidata
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Collagen alpha-1(XV) chain is a protein that in humans is encoded by the COL15A1 gene.

This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.

Further reading

• Myers JC, Kivirikko S, Gordon MK, et al. (1992). "Identification of a previously unknown human collagen chain, alpha 1(XV), characterized by extensive interruptions in the triple-helical region". Proc. Natl. Acad. Sci. U.S.A. 89 (21): 10144–8. doi:10.1073/pnas.89.21.10144. PMC 50294. PMID 1279671.
• Kivirikko S, Heinämäki P, Rehn M, et al. (1994). "Primary structure of the alpha 1 chain of human type XV collagen and exon-intron organization in the 3' region of the corresponding gene". J. Biol. Chem. 269 (7): 4773–9. PMID 8106446.
• Muragaki Y, Abe N, Ninomiya Y, et al. (1994). "The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen". J. Biol. Chem. 269 (6): 4042–6. PMID 8307960.
• Myers JC, Dion AS, Abraham V, Amenta PS (1997). "Type XV collagen exhibits a widespread distribution in human tissues but a distinct localization in basement membrane zones". Cell Tissue Res. 286 (3): 493–505. doi:10.1007/s004410050719. PMID 8929352.
• Hägg PM, Hägg PO, Peltonen S, et al. (1997). "Location of type XV collagen in human tissues and its accumulation in the interstitial matrix of the fibrotic kidney". Am. J. Pathol. 150 (6): 2075–86. PMC 1858337. PMID 9176399.
• Hägg PM, Muona A, Liétard J, et al. (1998). "Complete exon-intron organization of the human gene for the alpha1 chain of type XV collagen (COL15A1) and comparison with the homologous COL18A1 gene". J. Biol. Chem. 273 (28): 17824–31. doi:10.1074/jbc.273.28.17824. PMID 9651385.
• Ramchandran R, Dhanabal M, Volk R, et al. (1999). "Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin". Biochem. Biophys. Res. Commun. 255 (3): 735–9. doi:10.1006/bbrc.1999.0248. PMID 10049780.
• Li D, Clark CC, Myers JC (2000). "Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells". J. Biol. Chem. 275 (29): 22339–47. doi:10.1074/jbc.M000519200. PMID 10791950.
• Nishi M, Mizushima A, Nakagawara K, Takeshima H (2000). "Characterization of human junctophilin subtype genes". Biochem. Biophys. Res. Commun. 273 (3): 920–7. doi:10.1006/bbrc.2000.3011. PMID 10891348.
• Eklund L, Muona A, Liétard J, Pihlajaniemi T (2001). "Structure of the mouse type XV collagen gene, Col15a1, comparison with the human COL15A1 gene and functional analysis of the promoters of both genes". Matrix Biol. 19 (6): 489–500. doi:10.1016/S0945-053X(00)00090-1. PMID 11068203.
• Tomono Y, Naito I, Ando K, et al. (2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed in specialized basement membranes". Cell Struct. Funct. 27 (1): 9–20. doi:10.1247/csf.27.9. PMID 11937714.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Myers JC, Amenta PS, Dion AS, et al. (2007). "The molecular structure of human tissue type XV presents a unique conformation among the collagens". Biochem. J. 404 (3): 535–44. doi:10.1042/BJ20070201. PMC 1896284. PMID 17355226.