αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed by platelets. Furthermore, it is a receptor for phagocytosis on macrophages or dendritic cells.
As a drug target
Integrin αVβ3 is potential drug target because abnormal expression of v3 is linked to the development and progression of various diseases.
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- Novel Protein Agent Targets Cancer and Host of Other Diseases. June 2016
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