Ceftriaxone

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Ceftriaxone
Clinical data
Trade namesRocephin or Epicephin, Arixon, Elcefrin(LGls)
AHFS/Drugs.comMonograph
Pregnancy
category
  • AU: B1
Routes of
administration		Intravenous, intramuscular
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
Pharmacokinetic data
Bioavailabilityn/a
MetabolismNegligible
Elimination half-life5.8–8.7 hours
Excretion33–67% renal, 35–45% biliary
Identifiers
  • (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)->2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.070.347 Edit this at Wikidata
Chemical and physical data
FormulaC18H18N8O7S3
Molar mass554.58 g/mol g·mol−1
3D model (JSmol)
  • O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)CS\C4=N\C(=O)C(=O)NN4C)C(=O)O
  • InChI=1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/m1/s1 checkY
  • Key:VAAUVRVFOQPIGI-SPQHTLEESA-N checkY
  (verify)

Ceftriaxone (INN) /ˌsɛftraɪˈæksoʊn/ is an antibiotic useful for the treatment of a number of bacterial infections. It is a third-generation cephalosporin. Like other third-generation cephalosporins, it has broad-spectrum activity against Gram-positive bacteria and expanded Gram-negative coverage compared to second-generation agents. In most cases, it is considered to be equivalent to cefotaxime in terms of safety and efficacy. Ceftriaxone sodium is marketed by Hoffmann-La Roche under the trade name Rocephin.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[1]

Medical use

Ceftriaxone is used to treat a wide variety of serious infections caused by organisms that are resistant to most other antibiotics. It is often used (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the treatment of community-acquired or mild to moderate health care-associated pneumonia.

It is also a choice drug for treatment of bacterial meningitis caused by pneumococci, meningococci, Haemophilus influenzae, and susceptible enteric gram-negative rods, but not Listeria monocytogenes.[2]

Other uses included the treatment of acute bacterial otitis media, skin and skin structure infections, bone and joint infections, gonorrhea, intra-abdominal and urinary tract infections, pelvic inflammatory disease (PID), and bacterial septicemia. It also approved to be used in surgical (perioperative) prophylaxis.[3]

Pregnancy

Pregnancy category B. Ceftriaxone has not been observed to cause birth defects in animal studies, and preliminary studies in humans have shown no increase risk for birth defects.[4]

Breastfeeding

Low concentrations of ceftriaxone are excreted in breast milk. The manufacturer recommends that caution be exercised when administering ceftriaxone to women that breastfeed.[4]

Adverse effects

Ceftriaxone may precipitate in bile, causing biliary sludge and gallstones, especially in children. It may cause allergic reactions similar to those caused by penicillin. Due to the 3-8% cross allergenicity with penicillins, caution should be used in those with a history of severe allergies to penicillin. Other common side effects include local irritation at the injections site, rash, and diarrhea. Hypoprothrombinaemia and bleeding are specific side-effects. Haemolysis is reported.[5][6][7] It has also been reported to cause post renal failure in children.[8]

Contraindications

Ceftriaxone should not be used in those with an allergy to ceftriaxone or any component of the formulation. It should not be used in hyperbilirubinemic neonates, particularly those who are premature because ceftriaxone is reported to displace bilirubin from albumin binding sites. It is contraindicated with concomitant use with intravenous calcium-containing solutions/products in neonates (≤28 days) [9] even if administered through different infusion lines due to rare fatal cases of calcium-ceftriaxone precipitations in neonatal lungs and kidneys.[10]

Spectrum of activity

Like other third-generation cephalosporins, ceftriaxone is active against citrobacter, S. marcenscens, and beta-lactamase-producing strains of haemophilus and neisseria. However, unlike ceftazidime and cefoperazone, ceftriaxone does not have useful activity against Pseudomonas aeruginosa. It is not generally not active against enterobacter species, and its use should be avoided in the treatment of enterobacter infections even if the isolate appears susceptible because of the emergence of resistance. Like all other cephalosporins, it has no activity against enterococci, atypicals (Mycoplasma and Chlamydia), or Listeria.[2]

Mechanism of Action

Ceftriaxone inhibits bacterial cell wall synthesis by means of binding to the penicillin-binding proteins (PBPs). Inhibition of PBPs would in turn inhibit the transpeptidation step in peptidoglycan synthesis which is required for bacterial cell walls. Like other cephalosporins, ceftriaxone is bacteriocidal and exhibits time-dependent killing.[11]

Pharmacokinetics

The half-life is 7–8 hours. Like other third-generation cephalosporins, ceftriaxone penetrates body fluids and tissues well, and can achieve levels in the cerebrospinal fluid sufficient to inhibit most pathogens. The excretion is mainly through the biliary tract and no dose adjustment is required in renal impairment. With the exception cefoperazone, all other third-generation cephalosporins require dose adjustment in renal insufficiency.

Ceftriaxone can be administered intravenously and intramuscularly. It is not available orally. For most infections, ceftriaxone can be injected once every 24 hours at a dosage of 15–50 mg/kg/d. A single daily 1-g dose is usually sufficient. A dose of 2-g every 12 hours is recommended for the treatment of meningitis. A single intramuscular dose of 250 mg is recommended for the treatment of gonorrheal urethritis and cervicitis in conjunction with a single 1-g oral dose of azithromycin or doxycycline 100 mg orally twice daily for seven days to cover chlamydia co-infection. According to the Journal of Family Practice, Volume 60, NO 12, December 2011, the intramuscular dose of ceftriaxone (Rocephin) has been increased from 125 mg IM to 250 mg IM due to increasing resistance of the gonococcal bacteria. The dosage for acute ear infection in the very young is 50 mg/kg IM, one dose daily up to three days.

To reduce the pain of intramuscular injection, ceftriaxone may be reconstituted with 1% lidocaine.[12]

Chemistry

Ceftriaxone is a white crystalline powder readily soluble in water, sparingly soluble in methanol, and very slightly soluble in ethanol. The pH of a 1% aqueous solution is approximately 6.7.

The syn-configuration of the methoxyimino moiety confers resistance to β-lactamase enzymes produced by many Gram-negative bacteria. The stability of this configuration results in increased activity of ceftriaxone against otherwise-resistant Gram-negative bacteria. In place of the easily hydrolysed acetyl group of cefotaxime, ceftriaxone has a metabolically stable thiotriazinedione moiety.

Research

Ceftriaxone has also been investigated for efficacy in preventing relapse to cocaine addiction.[13]

Ceftriaxone seems to increase EAAT2 pump expression and activity[14] in the central nervous system and has therefore a potential to reduce glutamatergic toxicity.[15]

Ceftriaxone has been shown to have neuroprotective properties in a number of neurological disorders, including spinal muscular atrophy[16] and amyotrophic lateral sclerosis.[17] Despite earlier negative results in the 1990s, a large clinical trial was undertaken in 2006 to test ceftriaxone in ALS patients but was stopped early after it became clear that the results would not meet the pre-determined criteria for efficacy. [18]

References

  1. ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
  2. ^ a b Katzung, Bertram (2009). Basic and Clinical Pharmacology, Eleventh Edition. New York: McGraw-Hill. pp. 783–784. ISBN 978-0-07-160405-5.
  3. ^ Genetech USA. "Rochepin (ceftriaxone sodium) for injection" (PDF). Roche Group. Retrieved April 21, 2014.
  4. ^ a b "Ceftriaxone: Drug information". UpTpDate. Retrieved April 21, 2013.
  5. ^ Shiffman ML, Keith FB, Moore EW (December 1990). "Pathogenesis of ceftriaxone-associated biliary sludge. In vitro studies of calcium-ceftriaxone binding and solubility". Gastroenterology. 99 (6): 1772–8. PMID 2227290.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ^ Shrimali, JD; Patel, HV; Gumber, MR; Kute, VB; Shah, PR; Vanikar, AV; Trivedi, HL (Nov 2013). "Ceftriaxone induced immune hemolytic anemia with disseminated intravascular coagulation". Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine. 17 (6): 394–5. doi:10.4103/0972-5229.123465. PMC 3902580. PMID 24501497.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  7. ^ Guleria, VS; Sharma, N; Amitabh, S; Nair, V (Sep–Oct 2013). "Ceftriaxone-induced hemolysis". Indian journal of pharmacology. 45 (5): 530–1. doi:10.4103/0253-7613.117758. PMC 3793531. PMID 24130395.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  8. ^ Li, N.; Zhou, X.; Yuan, J.; Chen, G.; Jiang, H.; Zhang, W. (24 March 2014). "Ceftriaxone and Acute Renal Failure in Children". PEDIATRICS. 133 (4): e917–e922. doi:10.1542/peds.2013-2103. PMID 24664092.
  9. ^ "FDA Updates warning on Ceftriaxone-Calcium injection".
  10. ^ Bradley JS; Wassel RT; Lee L; Nambiar S (April 2009). "Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events". Pediatrics. 123 (4): e609–13. doi:10.1542/peds.2008-3080. PMID 19289450. {{cite journal}}: Cite has empty unknown parameter: |author-name-separator= (help); Unknown parameter |author-separator= ignored (help)
  11. ^ Ceftriaxone: Drug information. Uptodate.com. Retrieved Oct 2013.
  12. ^ Schichor A; Bernstein B; Weinerman H; Fitzgerald J; Yordan E; Schechter N (January 1994). "Lidocaine as a diluent for ceftriaxone in the treatment of gonorrhea. Does it reduce the pain of the injection?". Arch Pediatr Adolesc Med. 148 (1): 72–5. doi:10.1001/archpedi.1994.02170010074017. PMID 8143016. {{cite journal}}: Cite has empty unknown parameter: |author-name-separator= (help); Unknown parameter |author-separator= ignored (help)
  13. ^ Knackstedt LA; Melendez RI; Kalivas PW (August 2009). "Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine-seeking". Biol Psychiatry. 67 (1): 81–4. doi:10.1016/j.biopsych.2009.07.018. PMC 2795043. PMID 19717140. {{cite journal}}: Cite has empty unknown parameter: |author-name-separator= (help); Unknown parameter |author-separator= ignored (help)
  14. ^ Pharmacological evaluation of glutamate transporter 1 (GLT-1)-mediated neuroprotection following cerebral ischemia/reperfusion injury. Eur J Pharmacol. 2010 Jul 25;638(1-3):65-71. Epub 2010 Apr 24.
  15. ^ Lee SG, Su ZZ, Emdad L, Gupta P, Sarkar D, Borjabad A, Volsky DJ, Fisher PB (2008). "Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes". The Journal of Biological Chemistry. 283 (19): 13116–13123. doi:10.1074/jbc.M707697200. PMC 2442320. PMID 18326497.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  16. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/j.expneurol.2011.06.002, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1016/j.expneurol.2011.06.002 instead.
  17. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1038/nature03180, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1038/nature03180 instead.
  18. ^ "Statement on the Clinical Trial of Ceftriaxone". The Northeast ALS Consortium (NEALS). 8 August 2012. Retrieved 10 May 2013.

External links

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