Chlortetracycline
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| Clinical data | |
|---|---|
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Routes of administration | Oral, IV, topical |
| ATC code | |
| Pharmacokinetic data | |
| Bioavailability | 30% |
| Protein binding | 50 to 55% |
| Metabolism | Hepatic (75%) |
| Elimination half-life | 5.6 to 9 hours |
| Excretion | Renal and biliary |
| Identifiers | |
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| CAS Number | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| E number | E702 (antibiotics) |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.310 |
| Chemical and physical data | |
| Formula | C22H23ClN2O8 |
| Molar mass | 478.88 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 by Benjamin Minge Duggar working at Lederle Laboratories under the supervision of Yellapragada Subbarow. Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.[1] The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color.
In veterinary medicine, chlortetracycline is commonly used to treat conjunctivitis in cats.[2]
References
- ^ Jukes, Thomas H. Some historical notes on chlortetracycline. Reviews of Infectious Diseases 7(5):702-707 (1985).
- ^ Merck Veterinary Manual.
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