Collagen, type X, alpha 1

COL10A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GR3
Identifiers
Aliases	COL10A1, collagen type X alpha 1 chain
External IDs	OMIM: 120110; MGI: 88445; HomoloGene: 55466; GeneCards: COL10A1; OMA:COL10A1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	116,158,747 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	34,273,081 bp
RNA expression pattern
	Top expressed in
	tibia; ; periodontal fiber; ; buccal mucosa cell; ; cartilage tissue; ; mucosa of paranasal sinus; ; trabecular bone; ; visceral pleura; ; gallbladder; ; Achilles tendon; ; pancreatic epithelial cell;
	Top expressed in
	humerus; ; intercostal muscle; ; tibia; ; forearm; ; trachea; ; radius; ; epiphyseal plate; ; ulna; ; bones of pectoral girdle; ; human fetus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength;
Cellular component	cell cortex; collagen; endoplasmic reticulum lumen; extracellular region; extracellular matrix; extracellular space; collagen-containing extracellular matrix;
Biological process	skeletal system development; extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	1300
	12813
	ENSG00000123500
	ENSMUSG00000039462
	Q03692
	Q05306
	NM_000493
	NM_009925
	NP_000484
	NP_034055
	Wikidata
View/Edit Human	View/Edit Mouse

Collagen alpha-1(X) chain is a protein that in humans is a member of the collagen family encoded by the COL10A1 gene.^[5]^[6]

Template:PBB Summary

DDR2 is a collagen receptor for it.^[7]

Recent studies into the early detection of colon cancer have identified COL10A1 protein levels in serum as a potential diagnostic biomarker candidate to detect both adenoma lesions and tumor.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123500 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039462 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Apte S, Mattei MG, Olsen BR (Jul 1991). "Cloning of human alpha 1(X) collagen DNA and localization of the COL10A1 gene to the q21-q22 region of human chromosome 6". FEBS Lett. 282 (2): 393–6. doi:10.1016/0014-5793(91)80521-4. PMID 2037056.
^ "Entrez Gene: COL10A1 collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia)".
^ Leitinger B, Kwan AP (August 2006). "The discoidin domain receptor DDR2 is a receptor for type X collagen". Matrix Biol. 25 (6): 355–64. doi:10.1016/j.matbio.2006.05.006. PMID 16806867.
^ Solé X, Crous-Bou M, Cordero D, Olivares D, Guinó E, Sanz-Pamplona R, Rodriguez-Moranta F, Sanjuan X, de Oca J, Salazar R, Moreno V (September 2014). "Discovery and validation of new potential biomarkers for early detection of colon cancer". PLoS ONE. 9: e106748. doi:10.1371/journal.pone.0106748. PMC 4162553. PMID 25215506.{{cite journal}}: CS1 maint: unflagged free DOI (link)

References

Further reading