DXP reductoisomerase
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of DXR in complex with the substrate 1-deoxy-D-xylulose 5-phosphate | |||||||||
| Identifiers | |||||||||
| Symbol | DXP_reductoisom | ||||||||
| Pfam | PF02670 | ||||||||
| Pfam clan | CL0063 | ||||||||
| InterPro | IPR013512 | ||||||||
| SCOP2 | 1onn / SCOPe / SUPFAM | ||||||||
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| DXP reductoisomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.267 | ||||||||
| CAS no. | 210756-42-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
DXP reductoisomerase (1-deoxy-D-xylulose 5-phosphate reductoisomerase or DXR) is an enzyme that interconverts 1-deoxy-D-xylulose 5-phosphate (DXP) and 2-C-methyl-D-erythritol 4-phosphate (MEP).[1]
It is classified under EC 1.1.1.267.
It is part of the nonmevalonate pathway (MEP pathway), and it is inhibited by fosmidomycin.
It is normally abbreviated DXR, but it is sometimes named IspC, as the product of the ispC gene.
This enzyme is responsible for terpenoid biosynthesis in some organisms.[1] In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the non-mevalonate pathway for isoprenoid biosynthesis. The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with Mn2+ being most effective.
External links
- DXP+reductoisomerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
References
- ^ a b Takahashi S, Kuzuyama T, Watanabe H, Seto H (August 1998). "A 1-deoxy-D-xylulose-5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in the non-mevalonate pathway for terpenoid biosynthesis". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9879–84. doi:10.1073/pnas.95.17.9879. PMC 21430. PMID 9707569.