Yuk-ming Dennis Lo FRS (born c. 1963) is a Hong Kong scientist. He is a professor of chemical pathology at the Chinese University of Hong Kong. He is the director of the Li Ka Shing Institute of Health Sciences. Lo is a fellow of the Royal Society.
Lo was born in Hong Kong. His father was a medical doctor and his mother taught music. In 1983, at the age of 20, he attended Cambridge University and completed a pre-clinical degree before attending Oxford for clinical training. He later finished his PhD at Oxford. Lo has stated that he does not practice a religion but in his heart of hearts would have "to invoke something religious to explain everything right to the beginning."
After learning about a new method to detect small amounts of DNA called polymerase chain reaction from another researcher, Lo read a research paper describing the detection of tumor DNA in blood plasma. Lo wondered if it would be possible to detect fetal DNA in blood from a pregnant mother. In 1989, he published results that suggested fetal DNA did exist but only in low quantities. However, in 1997, Lo was successful in detecting fetal DNA in the plasma of a pregnant mother by using the male chromosome as a marker. He called the discovery like "finding your car's engine somewhere other than under the bonnet." This discovery has enabled a safer way for prenatal diagnosis of abnormalities in fetal development. In 2011, he developed a sequencing-based technology to determine the gender of the fetus earlier than an ultrasound. Lo was able to adapt this technology to use RNA, instead of DNA, to detect down-syndrome in unborn fetuses where previous methods could cause a miscarriage.
- State Natural Science Award from the State Council of China, 2005
- International Federation of Clinical Chemistry and Laboratory Medicine, 2006
- Abbott Award for Outstanding Contribution to Molecular Dianosticas
- US National Academy of Clinical Biochemistry Distinguished Scientist Award, 2006
- Sigi Zeiring Award from the American Association of Clinical Chemistry, 2009
- Fellow of the Royal Society, 2011
- Foreign Associate of the US National Academy of Sciences, 2013
- King Faisal Award 2014
- Future Science Prize, 2016
- Thomson Reuters Citation Laureate (in recognition of the high number of citations that rank Lo in the top 0.1% of his field world wide), 2016
- "Yuk-Ming Dennis lo, MD: AACC-NACB Award for Outstanding Contributions to Clinical Chemistry in a Selected Area of Research". American Association for Clinical Chemistry. Retrieved 6 September 2013.
- "Professor Yuk Ming Dennis Lo FRS". The Royal Society.
- "Encounters with Alumni from Greater China". Oxford University. August 2011. Retrieved 6 September 2013.
- Misia Landau (April 2012). "Inspiring Minds: Yuk-Ming Dennis Lo". 56 (4). Clinical Chemistry: 784–786. doi:10.1373/clinchem.2011.179069. Retrieved 6 September 2013. Cite journal requires
- ZoÎ Corbyn (31 August 2013). "Dennis Lo: 'Should parents be told about a disease their child might get?'". The Guardian. Retrieved 6 September 2013.
- Andrew Pollack (October 6, 2008). "Blood Tests Ease Search for Down Syndrome". The New York Times. Retrieved 20 September 2013.
- "Academic Profiles: Dennis Lo, Professor". The Chinese University of Hong Kong. Retrieved 6 September 2013.
- Siu, Phila (2016-09-20). "Hong Kong professor bags first-ever Chinese version of Nobel Prize". South China Morning Post. Retrieved 2019-09-13.