DNA polymerase alpha subunit 2

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesPOLA2, DNA polymerase alpha 2, accessory subunit
External IDsMGI: 99690 HomoloGene: 48121 GeneCards: POLA2
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for POLA2
Genomic location for POLA2
Band11q13.1Start65,261,920 bp[1]
End65,305,589 bp[1]
RNA expression pattern
PBB GE POLA2 204441 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 11: 65.26 – 65.31 MbChr 19: 5.94 – 5.96 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene.[5][6][7]


POLA2 has been shown to interact with PARP1.[8]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000014138 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024833 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Collins KL, Russo AA, Tseng BY, Kelly TJ (Dec 1993). "The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication". EMBO J. 12 (12): 4555–66. PMC 413886. PMID 8223465.
  6. ^ Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE (Jul 2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ɛ B-subunit gene POLE2". Nucleic Acids Res. 29 (13): 2810–21. doi:10.1093/nar/29.13.2810. PMC 55767. PMID 11433027.
  7. ^ "Entrez Gene: POLA2 polymerase (DNA directed), alpha 2 (70kD subunit)".
  8. ^ Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J (Apr 1998). "Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication". Nucleic Acids Res. 26 (8): 1891–8. doi:10.1093/nar/26.8.1891. PMC 147507. PMID 9518481.

Further reading[edit]

External links[edit]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA polymerase alpha subunit B