Portal:Viruses/Selected virus

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Portal:Viruses/Selected virus/1

Rotavirus

Rotavirus is a genus of double-stranded RNA viruses in the family Reoviridae. There are five species A–E; rotavirus A, the most common, causes over 90% of infections in humans. Rotavirus also infects animals, including livestock. The virus is transmitted by the faecal–oral route, with fewer than 100 virus particles being required for infection. Rotaviruses are stable in the environment and normal sanitary measures fail to protect against them. Effective rotavirus vaccines are the main prevention method.

The virus infects and damages the enterocytes lining the small intestine, causing gastroenteritis (sometimes referred to as "stomach flu," although the virus is not related to influenza). A viral toxin is responsible for some of the pathology. Rotavirus is the most common cause of severe diarrhoea among infants and young children. Almost every child worldwide has been infected with rotavirus at least once by the age of five. Over 500,000 children under five die from rotavirus infection each year and almost two million more become severely ill. Immunity develops with repeated infections and adults are rarely affected.


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Diagram of HIV structure

Human immunodeficiency virus (HIV) is a lentivirus, an RNA virus in the retrovirus family. Two types of HIV have been characterised: HIV-1 is the more virulent and is responsible for most infections worldwide; HIV-2 is mainly confined to West Africa. The genome consists of two copies of a single-stranded +RNA, which contains nine genes. The roughly spherical virus particle has a diameter of about 120 nm; it is enveloped and contains a conical capsid made of around 2,000 copies of the p24 protein. The envelope glycoprotein, a trimeric complex of gp120 and gp41, binds to CD4, the primary receptor on the host cell.

HIV infects key cells in the human immune system including CD4+ helper T cells, macrophages and dendritic cells. Infection leads to low levels of CD4+ T cells via several mechanisms, resulting in a progressive immunodeficiency disease known as AIDS. Transmission occurs by the transfer of bodily fluids including blood, semen and breast milk, in which the virus is present both as free virus particles and within infected immune cells.


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Electron micrograph of canine parvovirus

Canine parvovirus type 2 is a non-enveloped single-stranded DNA virus in the Parvoviridae family. The icosahedral viral capsid is only 20–26 nm in diameter, making it one of the smallest viruses. The genome is about 5000 nucleotides long. The virus is very similar to feline panleukopenia virus, another parvovirus, as well as mink enteritis and raccoon and fox parvoviruses. It infects dogs, wolves, foxes and other canids, big cats and occasionally domestic cats, but cannot infect humans.

A relatively new disease, canine parvovirus 2 infection was first recognised in 1978 and rapidly spread worldwide. The virus is transmitted by direct or indirect contact with faeces. The virus replicates in the lymphoid tissue in the throat, then spreads to the bloodstream to infect cells of the lymph nodes, intestinal crypts and bone marrow. The disease has two different types: the more common intestinal form causes severe vomiting and dysentery; the cardiac form affects in puppies under 8 weeks, causing respiratory or cardiovascular failure. Mortality can reach 91% in untreated cases. An effective vaccine is available.


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Type 3 poliovirus capsid

Poliovirus is a human enterovirus, an RNA virus in the Picornaviridae family, associated with the paralytic disease poliomyelitis. The icosahedral virus particle is about 30 nanometres in diameter and lacks an envelope. It contains a relatively short, single-stranded positive RNA genome of around 7500 nucleotides, which encodes about ten viral products. The virus has a fairly high mutation rate even for an RNA virus. There are three serotypes, each with a slightly different capsid protein; PV1 is the most common.

The virus only infects humans; 95% of infections are asymptomatic. Infection occurs via the faecal–oral route and viral replication occurs in the alimentary tract. The virus enters the host cell by binding to an immunoglobulin-like receptor, CD155. Fully assembled poliovirus leaves the cell 4–6 hours after initiation of infection. Poliovirus was first isolated in 1909 by Karl Landsteiner and Erwin Popper. Its genome was sequenced in 1981. Among the simplest clinically significant viruses, poliovirus is one of the best-characterised viruses, and has become a useful model for studying RNA viruses.


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X-ray crystallographic structure of the Norwalk virus capsid

Noroviruses are a genus of non-enveloped, single-stranded RNA viruses in the Caliciviridae family. The positive-sense RNA genome is approximately 7.5 kbp. Known noroviruses fall into five different genogroups (GI–GV); three groups infect humans, the other two mice, cattle and other bovines. All are considered strains of a single species, Norwalk virus.

Noroviruses are extremely contagious, with fewer than 20 virus particles being infectious. They are transmitted directly from person to person and indirectly via contaminated water and food. After infection, the virus replicates in the small intestine, causing acute gastroenteritis, which develops 24–48 hours after exposure and lasts for 24–60 hours. The characteristic symptoms include nausea, forceful vomiting, watery diarrhoea and abdominal pain. Infection is usually self-limiting and rarely severe. Noroviruses are the most common cause of viral gastroenteritis in humans, affecting around 267 million people a year and causing over 200,000 deaths, mainly in less-developed countries and in very young, elderly or immunosuppressed people. Hand washing with soap and water is effective in reducing transmission.


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X-ray crystallographic structure of the bovine papillomavirus capsid

Papillomaviruses are small non-enveloped DNA viruses that make up the Papillomaviridae family. Their circular double-stranded genome is around 8 kb. The icosahedral capsid is 55–60 nm in diameter. They infect humans, other mammals and some other vertebrates including birds, snakes and turtles. More than a hundred species are known, classified into 30 genera. All papillomaviruses replicate exclusively in epithelial cells of stratified squamous epithelium, which forms the skin and some mucosal surfaces, including the lining of the mouth, airways, genitals and anus.

Infection by most papillomaviruses is either asymptomatic or causes small benign tumours known as warts or papillomas. Francis Peyton Rous showed in 1935 that the cottontail rabbit papilloma virus could cause skin cancer in rabbits – the first time that a virus was shown to cause cancer in mammals – and papillomas caused by some virus types, including human papillomavirus 16 and 18, carry a risk of becoming cancerous if the infection persists. Papillomaviruses are associated with cancers of the cervix, vulva, vagina, penis, oropharynx and anus in humans.


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Electron micrograph of Sin Nombre virus, a hantavirus

Hantaviruses are a genus of RNA viruses in the Bunyaviridae family. The enveloped virion is 120–160 nm in diameter and contains a single-stranded –RNA genome with three segments. They infect many different species of rodent and can be transmitted to humans, in some cases causing serious disease. Hantaan River virus, the first known hantavirus, was discovered in 1976 as the cause of a novel haemorrhagic fever affecting combatants in the Korean War. Hantavirus haemorrhagic fever with renal syndrome, as the disease is now known, can also be caused by other hantaviruses, including Dobrava-Belgrade virus. Some hantaviruses, including Sin Nombre and Bayou, cause a pulmonary syndrome. Others have not yet been associated with disease.

Unlike other bunyaviruses, hantaviruses are not transmitted by arthropods. Rodents act as the vector, with transmission to humans usually occurring via contact with urine, saliva or faeces, by inhalation of aerosolised excreta or by bite. Little is understood about how hantaviruses cause disease; the main site of viral replication in the body is unknown. Rodent control is important in disease prevention.


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Electron micrograph of two Epstein–Barr virus particles

Epstein–Barr virus (EBV) (also human herpesvirus 4) is a DNA virus in the Herpesviridae family which infects humans. The virion is around 120–180 nm in diameter. Like all herpesviruses, the capsid is surrounded by a protein tegument, as well as an envelope. The double-stranded DNA genome is about 192 kb with around 85 genes, making it one of the more complex viruses.

Transmission is in saliva and genital secretions. The virus infects epithelial cells in the mouth and pharynx and B cells of the immune system, producing virions by budding. EBV also becomes latent in B cells, possibly in the bone marrow, allowing the infection to persist lifelong. In the latent state, the linear genome is made circular and replicates separately from the host DNA as an episome. Reactivation is thought to be triggered by the B cell responding to other infections. EBV infection is almost ubiquitous. Infectious mononucleosis or glandular fever can occur when first infection is delayed until adolescence or adulthood. EBV is associated with some types of cancer, including Burkitt's lymphoma and nasopharyngeal carcinoma. In people with HIV, it can cause hairy leukoplakia and central nervous system lymphomas.


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Electron micrograph of West Nile virus

West Nile virus (WNV) is a flavivirus, an RNA virus in the Flaviviridae family. The enveloped virion is 45–50 nm in diameter and contains a single-stranded +RNA genome of 11–12 kb, encoding ten proteins. The main natural hosts are passerine and other birds (the reservoir), and several species of Culex mosquito (the vector); transmission is by bite of the female. WNV can also infect humans, some non-human primates, and some other mammals, including horses, as well as reptiles and amphibians. Mammals form a dead end for the virus, as it cannot replicate sufficiently quickly in them to complete the cycle back to the mosquito.

First identified in Uganda in 1937, WNV caused only sporadic human disease until the 1990s, but is now endemic in Africa, Asia, Australia, the Middle East, Europe and the United States. A fifth of humans infected experience West Nile fever, a mild flu-like disease. In less than 1% of those infected, the virus invades the central nervous system, with symptoms including encephalitis, meningitis and flaccid paralysis. No antiviral treatment is effective. No vaccine is currently available; mosquito control is the main preventive measure.


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Diagram of adenovirus

Adenoviruses are a group of non-enveloped DNA viruses that make up the Adenoviridae family. At 90–100 nm in diameter, they are the largest viruses to lack an envelope. Unique spikes or fibres protrude from the icosahedral capsid, with knobs that bind to the receptor on the host cell. The linear double-stranded genome is 26 to 48 kb long, encodes 23 to 46 proteins, and has a 55 kDa protein attached to each end.

Adenoviruses infect a broad range of vertebrates, including humans, livestock, horses, dogs, bats and other mammals, as well as birds and reptiles, and usually cause infections of the upper respiratory tract. Transmission can occur by respiratory droplets or via faeces, with swimming pools being a common source of infection. A total of 57 serotypes have been found in humans; they cause a wide range of illnesses including mild respiratory infections, conjunctivitis, cystitis and gastroenteritis. In people with an immunodeficiency they can cause life-threatening multi-organ disease. No antiviral treatment or vaccine is currently available; hand washing is the best way to prevent infection. Adenoviruses are an important viral vector for gene therapy. An oncolytic adenovirus has been approved in China for the treatment of head and neck cancer.


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Electron micrograph of tobacco mosaic virus

Tobacco mosaic virus (TMV) is an RNA virus in the Virgaviridae family that infects a wide range of plants, including tobacco, tomato, pepper, other members of the Solanaceae family, and cucumber. The rod-shaped virus particle is around 300 nm long and 18 nm in diameter, and consists of a helical capsid made from 2130 copies of a single coat protein, which is wrapped around a positive-sense single-stranded RNA genome of 6400 bases. The coat protein and RNA can self-assemble to produce infectious virus.

Infection often causes characteristic patterns, such as "mosaic"-like mottling and discoloration on the leaves. TMV causes an economically important disease in tobacco plants. Transmission is frequently by human handling, and prevention of infection involves destroying infected plants, hand washing and crop rotation to avoid contaminated soil. TMV is one of the most stable viruses known. The fact that it does not infect animals and can readily be produced in gramme amounts has led to its use in numerous pioneering studies in virology and structural biology. TMV was the first virus to be discovered and the first to be crystallised.


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Electron micrograph of Acanthamoeba polyphaga mimivirus

Acanthamoeba polyphaga mimivirus (APMV) is the only species in the Mimivirus genus of the Mimiviridae family of DNA viruses. It infects the amoeba, Acanthamoeba polyphaga. Its non-enveloped icosahedral capsid is 400 nm in diameter, with protein filaments of 100 nm projecting from its surface. The APMV genome is a linear, double-stranded DNA molecule of around 1.1 megabases, encoding around 979 genes. This is comparable to the genome of some small bacteria. It encodes several proteins that had not been previously discovered in viruses, including aminoacyl tRNA synthetases.

APMV is as large as some small species of bacteria. When it was first discovered in 1992, it was thought to be a bacterium, and named Bradfordcoccus. APMV was not shown to be a virus until 2003, when it was the largest virus then discovered. It has since been overtaken by Megavirus chilensis, Pandoravirus and Pithovirus, all of which also infect amoebae. These and other large viruses have been called "nucleocytoplasmic large DNA viruses", an informal grouping of very large and complex DNA viruses.


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Cryo-electron microscopy image of Semliki Forest virus, an alphavirus

Alphaviruses are a genus of RNA viruses in the Togaviridae family. The spherical enveloped virion is 70 nm in diameter and contains a single-stranded, positive-sense RNA genome of 11–12 kb. Members of the genus infect humans, horses and other mammals, as well as fish, birds, other vertebrates and invertebrates. Some alphaviruses cause significant disease in humans, with arthritis, encephalitis, rashes and fever being the most frequently observed symptoms.

The first alphavirus to be discovered was western equine encephalitis virus, by Karl Friedrich Meyer in 1930, in horses with fatal encephalitis in San Joaquin Valley, California, USA. Three subgroups are now known, the Semliki Forest virus (also including o'nyong-nyong, chikungunya and Ross River viruses), eastern equine encephalitis virus (also including Venezuelan equine encephalitis virus (VEEV)) and Sindbis virus groups. Alphaviruses are transmitted by insect vectors, predominantly mosquitoes. Large mammals usually form dead-end hosts for the viruses, although the horse is a major reservoir for VEEV. No human vaccine or antiviral drug has been licensed. Prevention is predominantly by control of the insect vector.


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Electron micrograph of cauliflower mosaic virus particles

Cauliflower mosaic virus (CaMV) is a plant pararetrovirus in the Caulimoviridae family, which has similarities with hepadnaviruses such as hepatitis B virus. It predominantly infects members of the Brassicaceae (cabbage) family, including cauliflower and turnip; some strains can also infect Datura and Nicotiana species of the Solanaceae family. It is transmitted by aphid vectors, such as Myzus persicae. Symptoms include a mottled leaf pattern called "mosaic", necrotic lesions on the surface of infected leaves, stunted growth and deformation of the overall plant structure.

Although the viral genome is double-stranded DNA, the virus replicates via reverse transcription like a retrovirus. The icosahedral virion is 52 nm in diameter, and is built from 420 capsid protein subunits. The circular 8 kb genome encodes seven proteins, including a movement protein, which facilitates viral movement to neighbouring cells, and an insect transmission factor, which recognises a protein receptor at the tip of the aphid mouthparts. CaMV has several ways of evading the host defensive responses, which include interrupting salicylic acid-dependent signalling and decoying host silencing machinery. The virus has a strong constitutive (always on) promoter, CaMV 35S, which is widely used in plant genetic engineering.


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Structure of adeno-associated virus serotype 2

Adeno-associated viruses (AAVs) are small DNA viruses in the Parvoviridae family. They cannot complete their replication cycle without a helper virus, either an adenovirus or herpesvirus. In the absence of the helper, AAV integrates into the host genome at a specific site on human chromosome 19. The 20 nm icosahedral capsid lacks an envelope, and contains a single-stranded DNA genome of around 4.7 kb. AAV infects humans and some other primates without causing disease. It generates only a mild immune response, which consists mainly of neutralising antibodies. The best-studied serotype, AAV-2, infects nerve cells, liver cells, skeletal muscle and the smooth muscle of blood vessels, using heparan sulphate proteoglycan as its receptor.

Its low pathogenicity makes AAV an attractive basis for viral vectors for gene therapy. Alipogene tiparvovec to treat lipoprotein lipase deficiency was the first gene therapy to be licensed. Promising results have also been obtained in clinical trials with AAV-based gene therapy in haemophilia, congestive heart disease, Parkinson's disease and the rare eye disease Leber's congenital amaurosis.


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False-coloured electron micrograph of Hendra virus

Henipaviruses are a genus of RNA viruses in the Paramyxoviridae family. The variably shaped, 40–600 nm diameter, enveloped capsid contains a single-stranded, negative-sense RNA genome of 18.2 kb, encoding six proteins. The cellular receptor Ephrin-B2 is widely distributed in mammals. Their natural hosts are bats, mainly megabats (fruit bats or flying foxes) and some microbats. Bats infected with Hendra virus develop viraemia and shed virus in urine, faeces and saliva for around a week, but show no signs of disease. Henipaviruses can also infect humans and livestock, causing severe disease with high mortality, making the group a zoonootic disease.

The first henipavirus, Hendra virus, was discovered in 1994 as the cause of an outbreak in horses in Brisbane, Australia. Two other species are known, Nipah and Cedar viruses. Their emergence as human pathogens has been linked to increased contact between bats and humans, sometimes via an intermediate domestic animal host. Human disease has been confined to Australia and Asia, but related sequences have also been found in African bats. Only a veterinary vaccine against Hendra virus is available.


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False-coloured electron micrograph of Sputnik virophage

Sputnik virophage is a DNA virus, discovered in 2008, that infects Acanthamoeba protozoa. It is a satellite virus of the giant mamavirus. It requires mamavirus to infect the cell simultaneously to replicate, hijacking the virus factories that mamavirus creates and impairing its replication. Sputnik was the first satellite to be shown to inhibit the replication of its associated helper virus. Such viruses have been termed "virophages" or "virus eaters" – by analogy with bacteriophages, viruses that parasitise bacteria – but the distinction between virophages and other satellite viruses that infect plants, arthropods and mammals is disputed. Other virophages have since been discovered, including the Mavirus, Zamilon and Organic Lake virophages; all infect protists and all rely on nucleocytoplasmic large DNA viruses as helpers. They have been proposed to belong to a new family, Lavidaviridae.

Sputnik's non-enveloped icosahedral capsid is 50 nm in diameter, and contains a circular double-stranded DNA genome of 18.3 kb. Three of its 21 predicted proteins are thought to derive from mamavirus or the related mimivirus, suggesting that virophages and giant viruses can swap genes during their joint infection of Acanthamoeba, and also that virophages might mediate horizontal gene transfer between giant viruses.


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Diagram of hepatitis D virus

Hepatitis D virus or hepatitis delta virus (HDV) is a small RNA virus, the sole member of the Deltavirus genus. It infects humans. A satellite virus, it can only replicate in the presence of a hepatitis B (HBV) helper virus. The spherical virion is 36 nm in diameter, with an envelope containing three HBV proteins. The single-stranded, negative-sense, circular RNA genome of 1679 nucleotides is the smallest genome of any known animal virus. It has an unusual base composition for a virus that infects animals, and is extensively bound to itself to form a rod-shaped structure. These features have led to suggestions that HDV might be related to viroids, small unencapsidated circular RNAs that infect plants. Unlike viroids, HDV encodes a protein, hepatitis D antigen.

Both HDV and HBV enter liver cells using the sodium/bile acid cotransporter as their receptor. They are mainly transmitted via injecting drug use and blood products. An estimated 15–20 million people are infected with both viruses, which is associated with an increased risk of liver complications. Around one in five jointly infected patients die. The HBV vaccine protects against HDV.


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