Related to receptor tyrosine kinase
The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk. Template:PBB Summary
History
The gene encoding mouse RYK was first identified in 1992.[1] Subsequently cDNA encoding the RYK protein have been isolated from the following species.[2]
Structure
In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal domain, an extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.[2]
Function
RYK is involved in regulation of axon growth during development of the nervous system.[3]
References
- ^ Hovens, CM, Stacker, SA (1992). "RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs". Proc. Natl. Acad. Sci. USA. 89 (24): 11818–11822. doi:10.1073/pnas.89.24.11818. PMC 50648. PMID 1334548.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b Halford, MM, and Stacker, S.A. (2001). "Revelations of the RYK receptor". BioEssays. 23 (1): 34–45. doi:10.1002/1521-1878(200101)23:1<34::AID-BIES1005>3.0.CO;2-D. PMID 11135307.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Edmund R Hollis, Nao Ishiko, Ting Yu, Chin-Chun Lu, Ariela Haimovich, Kristine Tolentino, Alisha Richman, Anna Tury, Shih-Hsiu Wang, Maysam Pessian, Euna Jo, Alex Kolodkin, Yimin Zou. Ryk controls remapping of motor cortex during functional recovery after spinal cord injury. Nature Neuroscience 2016; doi: 10.1038/nn.4282