Zinc finger FYVE domain-containing protein 9

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ZFYVE9
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases ZFYVE9, MADHIP, NSP, PPP1R173, SARA, SMADIP, zinc finger FYVE-type containing 9
External IDs MGI: 2652838 HomoloGene: 3527 GeneCards: ZFYVE9
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ZFYVE9
Genomic location for ZFYVE9
Band 1p32.3 Start 52,142,094 bp[1]
End 52,346,686 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004799
NM_007323
NM_007324

NM_183300
NM_001347163

RefSeq (protein)

NP_004790
NP_015563

n/a

Location (UCSC) Chr 1: 52.14 – 52.35 Mb Chr 1: 108.64 – 108.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.[5] SARA contains a double zinc finger (FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.[6] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157077 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034557 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (December 1998). "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor". Cell. 95 (6): 779–791. doi:10.1016/S0092-8674(00)81701-8. PMID 9865696. 
  6. ^ Lin HK, Bergmann S, Pandolfi PP (September 2004). "Cytoplasmic PML function in TGF-beta signalling". Nature. 431 (7005): 205–211. doi:10.1038/nature02783. PMID 15356634.