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Transforming growth factor, beta receptor III
Symbols TGFBR3 ; BGCAN; betaglycan
External IDs OMIM600742 MGI104637 HomoloGene2436 GeneCards: TGFBR3 Gene
RNA expression pattern
PBB GE TGFBR3 204731 at tn.png
More reference expression data
Species Human Mouse
Entrez 7049 21814
Ensembl ENSG00000069702 ENSMUSG00000029287
UniProt Q03167 O88393
RefSeq (mRNA) NM_001195683 NM_011578
RefSeq (protein) NP_001182612 NP_035708
Location (UCSC) Chr 1:
91.68 – 91.91 Mb
Chr 5:
107.11 – 107.29 Mb
PubMed search [1] [2]

Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved directly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors.[1][2]

See also[edit]


  1. ^ Andres JL, Stanley K, et al. (1989). "Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta". J. Cell Biol. 109 (6 (Pt 1)): 3137–3145. doi:10.1083/jcb.109.6.3137. PMC 2115961. PMID 2592419. 
  2. ^ Andres JL, DeFalcis D, et al. (1992). "Binding of two growth factor families to separate domains of the proteoglycan betaglycan". J. Biol. Chem. 267 (9): 5927–5930. PMID 1556106. 

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