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Sialidase-3

From Wikipedia, the free encyclopedia

NEU3
Identifiers
AliasesNEU3, SIAL3, neuraminidase 3 (membrane sialidase), neuraminidase 3, membrane sialidase, neuraminidase 3
External IDsOMIM: 604617; MGI: 1355305; HomoloGene: 4847; GeneCards: NEU3; OMA:NEU3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006656

NM_016720

RefSeq (protein)

NP_057929

Location (UCSC)Chr 11: 74.99 – 75.02 MbChr 7: 99.46 – 99.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.[5][6]

Function

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This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.[6]

Interactions

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Sialidase-3 has been shown to interact with Grb2.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162139Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035239Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T (Aug 1999). "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem Biophys Res Commun. 261 (1): 21–7. doi:10.1006/bbrc.1999.0973. PMID 10405317.
  6. ^ a b "Entrez Gene: NEU3 sialidase 3 (membrane sialidase)".
  7. ^ Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, Obinata M, Tateno H, Suzuki H, Miyagi T (Jul 2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. doi:10.1074/jbc.M212200200. PMID 12730204.

Further reading

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