TECTB

TECTB
Identifiers
Aliases	TECTB, tectorin beta
External IDs	OMIM: 602653; MGI: 109574; HomoloGene: 7568; GeneCards: TECTB; OMA:TECTB - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q25.2 Start 112,283,400 bp End 112,305,038 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 D2|19 51.13 cM Start 55,169,165 bp End 55,184,745 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium liver right lobe of liver right lobe of thyroid gland putamen temporal lobe mesencephalon left lobe of thyroid gland substantia nigra ventricular zone Top expressed in vestibular sensory epithelium organ of Corti utricle epithelium of macula of utricle of membranous labyrinth embryo cochlea saccule epithelium of macula of saccule of membranous labyrinth vestibular membrane of cochlear duct stria vascularis More reference expression data BioGPS n/a
Gene ontology Molecular function extracellular matrix structural constituent Cellular component anchored component of membrane membrane extracellular region plasma membrane extracellular matrix Biological process C-terminal protein lipidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6975 21684 Ensembl ENSG00000119913 ENSMUSG00000024979 UniProt Q96PL2 O08524 RefSeq (mRNA) NM_058222 NM_009348 RefSeq (protein) NP_478129 NP_033374 Location (UCSC) Chr 10: 112.28 – 112.31 Mb Chr 19: 55.17 – 55.18 Mb PubMed search
Wikidata
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Beta-tectorin is a protein that in humans is encoded by the TECTB gene.

Function

The genes for alpha-tectorin and beta-tectorin (this protein) encode the major noncollagenous proteins of the tectorial membrane of the cochlea.

Further reading

• Legan PK, Rau A, Keen JN, Richardson GP (1997). "The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system". J. Biol. Chem. 272 (13): 8791–801. doi:10.1074/jbc.272.13.8791. PMID 9079715.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.