Tenascin-R

TNR
Identifiers
Aliases	TNR, TN-R, tenascin R, NEDSTO
External IDs	OMIM: 601995 MGI: 99516 HomoloGene: 124416 GeneCards: TNR
Gene location (Human)
Chr.	Chromosome 1 (human)
End	175,743,616 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	159,759,299 bp
RNA expression pattern
	Top expressed in
	Region I of hippocampus proper; ; entorhinal cortex; ; inferior ganglion of vagus nerve; ; medulla oblongata; ; subthalamic nucleus; ; superior vestibular nucleus; ; ventral tegmental area; ; postcentral gyrus; ; inferior olivary nucleus; ; Brodmann area 46;
	Top expressed in
	superior frontal gyrus; ; ciliary body; ; iris; ; facial motor nucleus; ; hippocampus proper; ; anterior horn of spinal cord; ; substantia nigra; ; Region I of hippocampus proper; ; habenula; ; temporal lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular region; cell surface; membrane raft; perineuronal net; collagen-containing extracellular matrix; extracellular matrix; Schaffer collateral - CA1 synapse; glutamatergic synapse;
Biological process	negative regulation of neuron projection development; positive regulation of synaptic transmission, glutamatergic; extracellular matrix organization; axon guidance; synapse organization; positive regulation of transmission of nerve impulse; neuron cell-cell adhesion; negative regulation of cell-cell adhesion; telencephalon cell migration; negative regulation of axon extension; locomotory exploration behavior; long-term potentiation; neuromuscular process controlling balance; regulation of neurogenesis; negative regulation of axon extension involved in regeneration; negative regulation of synaptic transmission; modulation of chemical synaptic transmission; associative learning; cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	7143
	21960
	ENSG00000116147
	ENSMUSG00000015829
	Q92752
	Q8BYI9
	NM_003285; NM_001328635
	NM_022312
	NP_001315564; NP_003276; NP_003276.3
	NP_071707
	Wikidata
View/Edit Human	View/Edit Mouse

Tenascin-R is a protein that in humans is encoded by the TNR gene.^[5]^[6]^[7]

Function

Tenascin-R (TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion), TNX (TNXB), and TNR.^[8] The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116147 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015829 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Carnemolla B, Leprini A, Borsi L, Querze G, Urbini S, Zardi L (Jun 1996). "Human tenascin-R. Complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24". J Biol Chem. 271 (14): 8157–60. doi:10.1074/jbc.271.14.8157. PMID 8626505.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Leprini A, Gherzi R, Siri A, Querze G, Viti F, Zardi L (Jan 1997). "The human tenascin-R gene". J Biol Chem. 271 (49): 31251–4. doi:10.1074/jbc.271.49.31251. PMID 8940128.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ ^a ^b "Entrez Gene: TNR tenascin R (restrictin, janusin)".
^ Erickson HP (October 1993). "Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions". Curr. Opin. Cell Biol. 5 (5): 869–76. doi:10.1016/0955-0674(93)90037-Q. PMID 7694605.

Function

References

Further reading