Climbazole

Climbazole
Clinical data
Routes of; administration	topical
ATC code	none;
Identifiers
	IUPAC name (RS)-1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one;
CAS Number	38083-17-9 ;
PubChem CID	37907;
ChemSpider	34752 ;
UNII	9N42CW7I54;
ChEBI	CHEBI:83499 ;
ChEMBL	ChEMBL1437764 ;
CompTox Dashboard (EPA)	DTXSID6046555 ;
ECHA InfoCard	100.048.870
Chemical and physical data
Formula	C15H17ClN2O2
Molar mass	292.76 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES CC(C)(C)C(=O)C(n1ccnc1)Oc2ccc(cc2)Cl;
	InChI InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3 ; Key:OWEGWHBOCFMBLP-UHFFFAOYSA-N ;
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Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff, seborrhoeic dermatitis and eczema.^[2] Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff.^[2] Its chemical structure and properties are similar to other azole fungicides such as ketoconazole, clotrimazole and miconazole.

Indications and formulations

It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.^{[citation needed]}

Side effects

It may cause localized irritation of the skin with symptoms including redness, rashes and itching.^{[citation needed]}

References

^ Chemical Properties of Climbazole Archived 2007-11-13 at the Wayback Machine
^ ^a ^b Wigger-Alberti W, Kluge K, Elsner P (August 2001). "[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]". Praxis. 90 (33): 1346–9. PMID 11534318.

[1] Chemical Properties of Climbazole Archived 2007-11-13 at the Wayback Machine

[pmid11534318-2] Wigger-Alberti W, Kluge K, Elsner P (August 2001). "[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]". Praxis. 90 (33): 1346–9. PMID 11534318.

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