POLE (gene): Difference between revisions

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{{PBB|geneid=5426}}
#REDIRECT [[DNA polymerase epsilon]]
'''DNA polymerase epsilon catalytic subunit''' is an [[enzyme]] that in humans is encoded by the ''POLE'' [[gene]].<ref name="pmid8020968">{{cite journal | author = Szpirer J, Pedeutour F, Kesti T, Riviere M, Syväoja JE, Turc-Carel C, Szpirer C | title = Localization of the gene for DNA polymerase epsilon (POLE) to human chromosome 12q24.3 and rat chromosome 12 by somatic cell hybrid panels and fluorescence in situ hybridization | journal = Genomics | volume = 20 | issue = 2 | pages = 223–6 | date = Aug 1994 | pmid = 8020968 | pmc = | doi = 10.1006/geno.1994.1156 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: POLE polymerase (DNA directed), epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5426| accessdate = }}</ref>
{{R from gene symbol}}

POLε, along with [[POLD1]], has recently been associated with multiple adenoma.<<ref name="pmid23263490">{{cite journal | author = Palles C, Cazier JB, Howarth KM, Domingo E, Jones AM, Broderick P, Kemp Z, Spain SL, Guarino E, Guarino Almeida E, Salguero I, Sherborne A, Chubb D, Carvajal-Carmona LG, Ma Y, Kaur K, Dobbins S, Barclay E, Gorman M, Martin L, Kovac MB, Humphray S, Lucassen A, Holmes CC, Bentley D, Donnelly P, Taylor J, Petridis C, Roylance R, Sawyer EJ, Kerr DJ, Clark S, Grimes J, Kearsey SE, Thomas HJ, McVean G, Houlston RS, Tomlinson I | title = Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas | journal = Nat. Genet. | volume = 45 | issue = 2 | pages = 136–44 | year = 2013 | pmid = 23263490 | pmc = 3785128 | doi = 10.1038/ng.2503 }}</ref>

==Interactions==
POLE has been shown to [[Protein-protein interaction|interact]] with [[RAD17]].<ref name=pmid14500819>{{cite journal | author = Post SM, Tomkinson AE, Lee EY | title = The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon | language = | journal = Nucleic Acids Res. | volume = 31 | issue = 19 | pages = 5568–75 | date = Oct 2003 | pmid = 14500819 | pmc = 206465 | doi = 10.1093/nar/gkg765 | url = | authorlink = | laysummary = | oclc = | id = | bibcode = | accessdate = | location = England | laydate = | format = | quote = | publisher = | issn = | laysource = }}</ref>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal | author = Popanda O, Thielmann HW | title = The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts. | journal = Biochim. Biophys. Acta | volume = 1129 | issue = 2 | pages = 155–60 | year = 1992 | pmid = 1730053 | doi = 10.1016/0167-4781(92)90480-N }}
*{{cite journal | author = Kesti T, Frantti H, Syväoja JE | title = Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon. | journal = J. Biol. Chem. | volume = 268 | issue = 14 | pages = 10238–45 | year = 1993 | pmid = 8486689 | doi = }}
*{{cite journal | author = Mozzherin DJ, Fisher PA | title = Human DNA polymerase epsilon: enzymologic mechanism and gap-filling synthesis. | journal = Biochemistry | volume = 35 | issue = 11 | pages = 3572–7 | year = 1996 | pmid = 8639508 | doi = 10.1021/bi952142p }}
*{{cite journal | author = Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM | title = The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 1817–23 | year = 1997 | pmid = 9121429 | pmc = 232028 | doi = }}
*{{cite journal | author = Coll JM, Hickey RJ, Cronkey EA, Jiang HY, Schnaper L, Lee MY, Uitto L, Syvaoja JE, Malkas LH | title = Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome. | journal = Oncol. Res. | volume = 9 | issue = 11-12 | pages = 629–39 | year = 1998 | pmid = 9563011 | doi = }}
*{{cite journal | author = Huang D, Pospiech H, Kesti T, Syväoja JE | title = Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase epsilon. | journal = Biochem. J. | volume = 339 | issue = 3 | pages = 657–65 | year = 1999 | pmid = 10215605 | pmc = 1220202 | doi = 10.1042/0264-6021:3390657 }}
*{{cite journal | author = Araújo SJ, Tirode F, Coin F, Pospiech H, Syväoja JE, Stucki M, Hübscher U, Egly JM, Wood RD | title = Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK. | journal = Genes Dev. | volume = 14 | issue = 3 | pages = 349–59 | year = 2000 | pmid = 10673506 | pmc = 316364 | doi = }}
*{{cite journal | author = Li Y, Pursell ZF, Linn S | title = Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. | journal = J. Biol. Chem. | volume = 275 | issue = 30 | pages = 23247–52 | year = 2000 | pmid = 10801849 | doi = 10.1074/jbc.M002548200 }}
*{{cite journal | author = Mäkiniemi M, Hillukkala T, Tuusa J, Reini K, Vaara M, Huang D, Pospiech H, Majuri I, Westerling T, Mäkelä TP, Syväoja JE | title = BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 30399–406 | year = 2001 | pmid = 11395493 | doi = 10.1074/jbc.M102245200 }}
*{{cite journal | author = Fuss J, Linn S | title = Human DNA polymerase epsilon colocalizes with proliferating cell nuclear antigen and DNA replication late, but not early, in S phase. | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8658–66 | year = 2002 | pmid = 11741962 | doi = 10.1074/jbc.M110615200 }}
*{{cite journal | author = Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T | title = A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 40362–7 | year = 2002 | pmid = 12171929 | doi = 10.1074/jbc.M206194200 }}
*{{cite journal | author = Post SM, Tomkinson AE, Lee EY | title = The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. | journal = Nucleic Acids Res. | volume = 31 | issue = 19 | pages = 5568–75 | year = 2003 | pmid = 14500819 | pmc = 206465 | doi = 10.1093/nar/gkg765 }}
*{{cite journal | author = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | year = 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }}
*{{cite journal | author = Clark AG, Glanowski S, Nielsen R, Thomas PD, Kejariwal A, Todd MA, Tanenbaum DM, Civello D, Lu F, Murphy B, Ferriera S, Wang G, Zheng X, White TJ, Sninsky JJ, Adams MD, Cargill M | title = Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. | journal = Science | volume = 302 | issue = 5652 | pages = 1960–3 | year = 2003 | pmid = 14671302 | doi = 10.1126/science.1088821 }}
*{{cite journal | author = Rytkönen AK, Vaara M, Nethanel T, Kaufmann G, Sormunen R, Läärä E, Nasheuer HP, Rahmeh A, Lee MY, Syväoja JE, Pospiech H | title = Distinctive activities of DNA polymerases during human DNA replication. | journal = FEBS J. | volume = 273 | issue = 13 | pages = 2984–3001 | year = 2006 | pmid = 16762037 | doi = 10.1111/j.1742-4658.2006.05310.x }}
*{{cite journal | author = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry. | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
{{refend}}

{{gene-12-stub}}
{{DNA replication|state=collapsed}}

Revision as of 20:01, 16 November 2014

Template:PBB DNA polymerase epsilon catalytic subunit is an enzyme that in humans is encoded by the POLE gene.[1][2]

POLε, along with POLD1, has recently been associated with multiple adenoma.<[3]

Interactions

POLE has been shown to interact with RAD17.[4]

References

  1. ^ Szpirer J, Pedeutour F, Kesti T, Riviere M, Syväoja JE, Turc-Carel C, Szpirer C (Aug 1994). "Localization of the gene for DNA polymerase epsilon (POLE) to human chromosome 12q24.3 and rat chromosome 12 by somatic cell hybrid panels and fluorescence in situ hybridization". Genomics. 20 (2): 223–6. doi:10.1006/geno.1994.1156. PMID 8020968.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ "Entrez Gene: POLE polymerase (DNA directed), epsilon".
  3. ^ Palles C, Cazier JB, Howarth KM, Domingo E, Jones AM, Broderick P, Kemp Z, Spain SL, Guarino E, Guarino Almeida E, Salguero I, Sherborne A, Chubb D, Carvajal-Carmona LG, Ma Y, Kaur K, Dobbins S, Barclay E, Gorman M, Martin L, Kovac MB, Humphray S, Lucassen A, Holmes CC, Bentley D, Donnelly P, Taylor J, Petridis C, Roylance R, Sawyer EJ, Kerr DJ, Clark S, Grimes J, Kearsey SE, Thomas HJ, McVean G, Houlston RS, Tomlinson I (2013). "Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas". Nat. Genet. 45 (2): 136–44. doi:10.1038/ng.2503. PMC 3785128. PMID 23263490.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Post SM, Tomkinson AE, Lee EY (Oct 2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19). England: 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help)CS1 maint: multiple names: authors list (link)

Further reading

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