DNA polymerase delta

From Wikipedia, the free encyclopedia
Jump to: navigation, search
DNA-directed DNA polymerase
Identifiers
EC number 2.7.7.7
CAS number 9012-90-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

DNA polymerase delta is an enzyme complex found in eukaryotes that is involved in DNA replication and repair. The DNA polymerase delta complex consists of 4 subunits: POLD1, POLD2, POLD3, and POLD4.[1] DNA Pol δ is the enzyme used primarily for lagging strand synthesis. It exhibits increased processivity when interacting with the proliferating cell nuclear antigen (PCNA). As well, the multisubunit protein replication factor C, through its role as the as clamp loader for PCNA (whichinvolves catalysing the loading of PCNA on to DNA) is important for DNA Pol δ function.

References[edit]

  1. ^ Liu G, Warbrick E (October 2006). "The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins". Biochem. Biophys. Res. Commun. 349 (1): 360–6. doi:10.1016/j.bbrc.2006.08.049. PMID 16934752. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.