ALOX12

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Arachidonate 12-lipoxygenase
Protein ALOX12 PDB 2ABU.png
Rendering based on PDB 2ABU.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ALOX12 ; 12-LOX; 12S-LOX; LOG12
External IDs OMIM152391 MGI87998 HomoloGene560 ChEMBL: 3687 GeneCards: ALOX12 Gene
EC number 1.13.11.31
RNA expression pattern
PBB GE ALOX12 207206 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 239 11684
Ensembl ENSG00000108839 ENSMUSG00000000320
UniProt P18054 P39655
RefSeq (mRNA) NM_000697 NM_007440
RefSeq (protein) NP_000688 NP_031466
Location (UCSC) Chr 17:
6.9 – 6.91 Mb
Chr 11:
70.24 – 70.26 Mb
PubMed search [1] [2]

Arachidonate 12-lipoxygenase, 12S-type is an enzyme that in humans is encoded by the ALOX12 gene.[1][2]

Interactions[edit]

ALOX12 has been shown to interact with Keratin 5[3] and LMNA.[3]

References[edit]

  1. ^ Funk C, Funk L, FitzGerald G, Samuelsson B (May 1992). "Characterization of human 12-lipoxygenase genes". Proceedings of the National Academy of Sciences of the United States of America 89 (9): 3962–6. doi:10.1073/pnas.89.9.3962. PMC 525611. PMID 1570320. 
  2. ^ "Entrez Gene: ALOX12 arachidonate 12-lipoxygenase". 
  3. ^ a b Tang K, Finley R, Nie D, Honn K (Mar 2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening". Biochemistry 39 (12): 3185–91. doi:10.1021/bi992664v. PMID 10727209. 

Further reading[edit]

  • Yoshimoto T, Arakawa T, Hada T, Yamamoto S, Takahashi E (Dec 1992). "Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene". The Journal of Biological Chemistry 267 (34): 24805–9. PMID 1447217. 
  • Izumi T, Hoshiko S, Rådmark O, Samuelsson B (Oct 1990). "Cloning of the cDNA for human 12-lipoxygenase". Proceedings of the National Academy of Sciences of the United States of America 87 (19): 7477–81. doi:10.1073/pnas.87.19.7477. PMC 54770. PMID 2217179. 
  • Yoshimoto T, Yamamoto Y, Arakawa T, Suzuki H, Yamamoto S, Yokoyama C et al. (Nov 1990). "Molecular cloning and expression of human arachidonate 12-lipoxygenase". Biochemical and Biophysical Research Communications 172 (3): 1230–5. doi:10.1016/0006-291X(90)91580-L. PMID 2244907. 
  • Funk C, Furci L, FitzGerald G (Aug 1990). "Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase". Proceedings of the National Academy of Sciences of the United States of America 87 (15): 5638–42. doi:10.1073/pnas.87.15.5638. PMC 54382. PMID 2377602. 
  • Flatman S, Morgan A, McDonald-Gibson R, Davey A, Jonas G, Slater T (May 1988). "12-Lipoxygenase activity in human uterine cervix". Prostaglandins, Leukotrienes, and Essential Fatty Acids 32 (2): 87–94. doi:10.1016/0952-3278(88)90101-9. PMID 3406043. 
  • Wong P, Westlund P, Hamberg M, Granström E, Chao P, Samuelsson B (Aug 1985). "15-Lipoxygenase in human platelets". The Journal of Biological Chemistry 260 (16): 9162–5. PMID 3926763. 
  • Nakamura M, Ueda N, Kishimoto K, Yoshimoto T, Yamamoto S, Ishimura K (Mar 1995). "Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells". The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society 43 (3): 237–44. doi:10.1177/43.3.7868854. PMID 7868854. 
  • Hussain H, Shornick L, Shannon V, Wilson J, Funk C, Pentland A et al. (Jan 1994). "Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis". The American Journal of Physiology 266 (1 Pt 1): C243–53. PMID 8304420. 
  • Arora J, Lysz T, Zelenka P (Jun 1996). "A role for 12(S)-HETE in the response of human lens epithelial cells to epidermal growth factor and insulin". Investigative Ophthalmology & Visual Science 37 (7): 1411–8. PMID 8641843. 
  • Hagmann W, Gao X, Timar J, Chen Y, Strohmaier A, Fahrenkopf C et al. (Nov 1996). "12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization". Experimental Cell Research 228 (2): 197–205. doi:10.1006/excr.1996.0317. PMID 8912711. 
  • Nakamura M, Yamamoto S, Ishimura K (May 1997). "Subcellular localization of arachidonate 12-lipoxygenase and morphological effect of its overexpression on murine keratinocytes". Cell and Tissue Research 288 (2): 327–34. doi:10.1007/s004410050818. PMID 9082968. 
  • Nigam S, Kumar G, Sutherland M, Schewe T, Ikawa H, Yamasaki Y et al. (Sep 1999). "Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma". International Journal of Cancer. Journal International Du Cancer 82 (6): 827–31. doi:10.1002/(SICI)1097-0215(19990909)82:6<827::AID-IJC10>3.0.CO;2-Q. PMID 10446449. 
  • Tang K, Finley R, Nie D, Honn K (Mar 2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening". Biochemistry 39 (12): 3185–91. doi:10.1021/bi992664v. PMID 10727209. 
  • Tornhamre S, Elmqvist A, Lindgren J (Apr 2000). "15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation". Biochimica Et Biophysica Acta 1484 (2-3): 298–306. doi:10.1016/S1388-1981(00)00017-2. PMID 10760478. 
  • Chen B, Tsai T, Huang H, Chen L, Chang W, Tsai S et al. (2003). "Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene". Journal of Biomedical Science 9 (2): 156–65. doi:10.1159/000048212. PMID 11914583. 
  • Winer I, Normolle D, Shureiqi I, Sondak V, Johnson T, Su L et al. (Oct 2002). "Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis". Melanoma Research 12 (5): 429–34. doi:10.1097/00008390-200209000-00003. PMID 12394183. 
  • Gu J, Wen Y, Mison A, Nadler J (Feb 2003). "12-lipoxygenase pathway increases aldosterone production, 3',5'-cyclic adenosine monophosphate response element-binding protein phosphorylation, and p38 mitogen-activated protein kinase activation in H295R human adrenocortical cells". Endocrinology 144 (2): 534–43. doi:10.1210/en.2002-220580. PMID 12538614. 
  • Fridman C, Ojopi E, Gregório S, Ikenaga E, Moreno D, Demetrio F et al. (Feb 2003). "Association of a new polymorphism in ALOX12 gene with bipolar disorder". European Archives of Psychiatry and Clinical Neuroscience 253 (1): 40–3. doi:10.1007/s00406-003-0404-y. PMID 12664313.