Alclometasone

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Alclometasone
Alclometasone.svg
Systematic (IUPAC) name
[7-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
Clinical data
Trade names Aclovate
AHFS/Drugs.com monograph
MedlinePlus a604021
Legal status Rx Only (US)
Routes topical
Identifiers
CAS number 66734-13-2 YesY
ATC code D07AB10 S01BA10
PubChem CID 5311000
DrugBank DB00240
ChemSpider 4470541 YesY
UNII 136H45TB7B YesY
KEGG D01820 YesY
ChEBI CHEBI:53776 YesY
ChEMBL CHEMBL1201361 N
Chemical data
Formula C28H37ClO7 
Mol. mass 521.042 g/mol
 N (what is this?)  (verify)

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.

The prodrug alclometasone dipropionate is marketed as Aclovate by GlaxoSmithKline.

Pharmacology[edit]

Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications[edit]

Alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including:

Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

Contraindications[edit]

  • hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
  • cutaneous tuberculosis
  • chicken pox
  • perioral dermatitis
  • acne
  • rosacea
  • open wounds
  • trophic ulcers
  • viral infection of skin
  • skin manifestations of syphilis

Side effects[edit]

Adverse reactions (sometimes, less than 1-2% cases) include:

How supplied[edit]

Alclometasone as Aclovate is supplied in:

  • Cream; Topical; 0.05%
  • Ointment; Topical; 0.05%