From Wikipedia, the free encyclopedia
Jump to: navigation, search
Systematic (IUPAC) name
[7-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
Clinical data
Trade names Aclovate
AHFS/ monograph
MedlinePlus a604021
  • Rx Only (US)
66734-13-2 YesY
D07AB10 S01BA10
PubChem CID 5311000
DrugBank DB00240 YesY
ChemSpider 4470541 YesY
UNII 136H45TB7B YesY
KEGG D01820 YesY
ChEBI CHEBI:53776 YesY
Chemical data
Formula C28H37ClO7
521.042 g/mol
 N (what is this?)  (verify)

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.

The prodrug alclometasone dipropionate is marketed as Aclovate by GlaxoSmithKline.


Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).


Alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including:

Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.


  • hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
  • cutaneous tuberculosis
  • chicken pox
  • perioral dermatitis
  • acne
  • rosacea
  • open wounds
  • trophic ulcers
  • viral infection of skin
  • skin manifestations of syphilis

Side effects[edit]

Adverse reactions (sometimes, less than 1-2% cases) include:

How supplied[edit]

Alclometasone as Aclovate is supplied in:

  • Cream; Topical; 0.05%
  • Ointment; Topical; 0.05%