Fluocinonide

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Fluocinonide
Fluocinonide.png
Systematic (IUPAC) name
6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate
Clinical data
Trade names Lidex
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a601054
Pregnancy cat. C
Legal status Prescription Only (S4) (AU) POM (UK) -only (US)
Routes topical
Pharmacokinetic data
Metabolism hepatic
Identifiers
CAS number 356-12-7 YesY
ATC code C05AA11 D07AC08
PubChem CID 9642
DrugBank DB01047
ChemSpider 9265 YesY
UNII 2W4A77YPAN YesY
KEGG D00325 YesY
ChEMBL CHEMBL1501 YesY
Chemical data
Formula C26H32F2O7 
Mol. mass 494.525 g/mol
 YesY (what is this?)  (verify)

Fluocinonide (Fluonex, Lidex, Lidex-E, Lonide, Lyderm, and Vanos)[1] is a potent glucocorticoid steroid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.

The usual prescription concentration is 0.05% as a topical cream, ointment, or gel. The application area should normally not be covered after application. In certain cases, the physician may recommend the use of an occlusive dressing after application to increase the rate and depth of absorption. The frequency of application depends on the condition being treated and the area affected, but most often it should be applied 2 to 4 times a day.[2]

Fluocinonide ranks as a "high-potency" (second-highest rank) topical corticosteroid. Minimal amounts should be used for a minimal length of time to avoid the occurrence of adverse effects.[medical citation needed]

Fluocinonide should not be used if infection is present. It should not be applied to the eyes or to sensitive areas such as the genitals or anus.[medical citation needed]

A common potential adverse effect is skin atrophy (thinning of the skin). Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal axis (HPA) suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.

Fluocinonide should be used with caution when treating children, pregnant women, nursing mothers, and anyone using the medication for longer than two weeks.

Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs.[3] Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure.[4]

References[edit]

  1. ^ MedlinePlus Drug Information: Fluocinonide Topical
  2. ^ "Fluocinonide Topical". MedlinePlus. US National Library of Medicine, NIH. Retrieved 6 March 2014. 
  3. ^ Dog Allergies www.squidoo.com/dogallergy
  4. ^ Zenoble RD, Kemppainen RJ . (1987-09-15). "Adrenocortical suppression by topically applied corticosteroids in healthy dogs". J Am Vet Med Assoc 191 (6): 685–8. PMID 2824410.