|Systematic (IUPAC) name|
|Mol. mass||420.315 g/mol|
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Bromperidol (marketed as Bromidol, Bromodol) is a drug which is a butyrophenone derivative. It is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia. It was discovered at Janssen Pharmaceutica in 1966.
Antipsychotic drugs such as Bromperidol have been used for treating patients with schizophrenia for many years. Long‐acting depot injections of these types of drugs are extensively used as a means of long‐term maintenance treatment.
The characteristics of the side-effects of bromperidol was investigated in 33 acutely exacerbated Schizophrenic patients. The most frequently observed side-effects were extrapyramidal symptoms. Acute dystonia developed in 10 of 33 patients, and the mean age was significantly lower (P < 0.05) in patients with dystonia (27.3 ± 6.2 years) than that in patients without dystonia (41.5 ± 12.9 years).
- Poldinger W, Bures E, Haage H, Clinical study with bromperidol, a new butyrophenone derivative, Int Pharmacopsychiatry. 1977;12(1):20-4.
- Dubinsky B, McGuire JL, Niemegeers CJ, Janssen PA, Weintraub HS, McKenzie BE, Bromperidol, a new butyrophenone neuroleptic: a review, Psychopharmacology (Berl). 1982;78(1):1-7.
- Yasui-furukori, N., Kondo, T., & Ishida, M. (2002). The characteristics of side-effects of bromperidol in schizophrenic patients, (December 2000), 103–106.
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