Aplindore

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aplindore
Aplindore.png
Systematic (IUPAC) name
(2S)-2-[(phenylmethylamino)methyl]-2,3,7,9-tetrahydro-[1,4]dioxino[3,2-e]indol-8-one
Clinical data
Legal status ?
Identifiers
CAS number 189681-71-8 YesY
ATC code None
PubChem CID 158784
ChemSpider 139676 YesY
UNII Q5O76TA0ML YesY
KEGG D03214 YesY
ChEMBL CHEMBL2110659
Chemical data
Formula C18H18N2O3 
Mol. mass 310.346 g/mol
 YesY (what is this?)  (verify)

Aplindore (DAB-452) is a drug which acts as a partial agonist selective for the dopamine receptor D2.[1] It is being developed by the pharmaceutical company Neurogen as a treatment for Parkinson's disease and restless legs syndrome.

On December 23rd[when?] Neurogen was acquired by Ligand Pharmaceuticals. Rights to Aplindore were given to Ligand around time of merger. As of 2008, Phase II was completed and Ligand.

Upon reviewing company website (Ligand.com) this drug is currently not listed at the moment due to several programs already partnered with GSK. GSK holds a significant share of the drug RLS drug programs on the market with Requip XR and the recent FDA approval of Horizant. To prevent any direct competition and losing strong ties with GSK, Aplindore is not listed at the moment on Lidgand website. If this medication were to reach phase III, this could adversely effect Ligand`s portfolio of partnered and unpartnered assets. By electing not to list the drug on company website, Ligand maintains the appearance that they are "currently actively seeking a partner" when a potential investor inquirers about drug development via email.

References[edit]

  1. ^ Heinrich JN, Brennan J, Lai MH, Sullivan K, Hornby G, Popiolek M, Jiang LX, Pausch MH, Stack G, Marquis KL, Andree TH. Aplindore (DAB-452), a high affinity selective dopamine D2 receptor partial agonist. European Journal of Pharmacology. 2006 Dec 15;552(1-3):36-45. PMID 17056032