Ciclindole

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Ciclindole
Ciclindole.png
Systematic (IUPAC) name
N,N-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-3-amine
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Identifiers
CAS number 32211-97-5
ATC code None
PubChem CID 36082
ChemSpider 33189
UNII CXJ7G6BYD7 YesY
KEGG D03619
ChEMBL CHEMBL2104160
Chemical data
Formula C14H18N2 
Molecular mass 214.31 g/mol

Ciclindole (INN; WIN-27,147-2), also known as cyclindole (USAN), is an antipsychotic with a tricyclic structure that was never marketed.[1][2] It displaces spiperone binding in vitro and elevates dopamine levels in the striatum, indicating it acts as a D2 receptor antagonist.[2]

Synthesis[edit]

Cyclindole synthesis: Aram Mooradian; Sterling Drug Inc. U.S. Patent 3,959,309

See also[edit]

References[edit]

  1. ^ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. 
  2. ^ a b Wood PL, McQuade PS (1984). "Ciclindole and flucindole: novel tetrahydrocarbazolamine neuroleptics". Progress in Neuro-psychopharmacology & Biological Psychiatry 8 (4-6): 773–7. doi:10.1016/0278-5846(84)90057-5. PMID 6152347.