CDC6

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Cell division cycle 6
PDB 2cch EBI.jpg
Rendering of 2CCH
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CDC6 ; CDC18L; HsCDC18; HsCDC6
External IDs OMIM602627 MGI1345150 HomoloGene68172 GeneCards: CDC6 Gene
RNA expression pattern
PBB GE CDC6 203968 s at tn.png
PBB GE CDC6 203967 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 990 23834
Ensembl ENSG00000094804 ENSMUSG00000017499
UniProt Q99741 O89033
RefSeq (mRNA) NM_001254 NM_001025779
RefSeq (protein) NP_001245 NP_001020950
Location (UCSC) Chr 17:
38.44 – 38.46 Mb
Chr 11:
98.91 – 98.92 Mb
PubMed search [1] [2]

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.[1][2]

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during the cell cycle is regulated through its phosphorylation by cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through a transcriptional control mechanism involving E2F proteins.[3]

Interactions[edit]

CDC6 has been shown to interact with ORC1L,[2][4] ORC2L,[4][5] Cyclin A2,[2][6] PPP2R3B,[7] MCM3,[5][8] PPP2R3A,[9] MCM7[4][8] and PSKH1.[6]

See also[edit]

References[edit]

  1. ^ Williams RS, Shohet RV, Stillman B (February 1997). "A human protein related to yeast Cdc6p". Proc Natl Acad Sci U S A 94 (1): 142–7. doi:10.1073/pnas.94.1.142. PMC 19260. PMID 8990175. 
  2. ^ a b c Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A (May 1998). "Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase". Mol Cell Biol 18 (5): 2758–67. PMC 110655. PMID 9566895. 
  3. ^ "Entrez Gene: CDC6 cell division cycle 6 homolog (S. cerevisiae)". 
  4. ^ a b c Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  5. ^ a b Méndez, J; Stillman B (November 2000). "Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8602–12. doi:10.1128/MCB.20.22.8602-8612.2000. ISSN 0270-7306. PMC 102165. PMID 11046155. 
  6. ^ a b Petersen, B O; Lukas J; Sørensen C S; Bartek J; Helin K (January 1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. (ENGLAND) 18 (2): 396–410. doi:10.1093/emboj/18.2.396. ISSN 0261-4189. PMC 1171134. PMID 9889196. 
  7. ^ Yan, Z; Fedorov S A; Mumby M C; Williams R S (February 2000). "PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells". Mol. Cell. Biol. (UNITED STATES) 20 (3): 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. ISSN 0270-7306. PMC 85219. PMID 10629059. 
  8. ^ a b Fujita, M; Yamada C; Goto H; Yokoyama N; Kuzushima K; Inagaki M; Tsurumi T (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. (UNITED STATES) 274 (36): 25927–32. doi:10.1074/jbc.274.36.25927. ISSN 0021-9258. PMID 10464337. 
  9. ^ Davis, Anthony J; Yan Zhen; Martinez Bobbie; Mumby Marc C (June 2008). "Protein Phosphatase 2A Is Targeted to Cell Division Control Protein 6 by a Calcium-binding Regulatory Subunit". J. Biol. Chem. (United States) 283 (23): 16104–14. doi:10.1074/jbc.M710313200. ISSN 0021-9258. PMC 2414307. PMID 18397887. 

Further reading[edit]