At first he studied architecture and later it is shown up in his manga works with drawing huge structures. This became one of his general theme that makes his manga unique. His works are usually in black and white. He is also an avid fan of Western video games (Metro 2033, Elder Scrolls: Morrowind, Halo etc.) over Japanese or Asian video games.
Blame! - Nihei's first work, detailing the adventures of Killy as he searches for a human with compatible genes to save the world. Originally published in Afternoon, it also gained a 6 episode ONA.
NOiSE - A prequel to Blame!, in which a police officer investigates the murder of a gang. Originally publishing in Afternoon.
Abara - Published in Ultra Jump, Abara follows Denji Kudou, a man able to transform into a Gauna – a creature with bone-like armor and weaponry.
Biomega - Zouichi Kanoe and the AI in his motorbike set out to find humans resistant to N5S, a virus that turns people into zombie-like "Drones". Originally appeared in Young Magazine.
Knights of Sidonia - Nihei's latest series set in the far future about a human colony ship's war against an elusive alien race known as the "Gauna". It is currently running in Afternoon and is the first of Nihei's works to be adapted into a TV series.
Bitch's Life - An erotic illustrations book, featuring contributions from over twenty manga artists; four of which come from Nihei.
Blame! and So On - Published in 2003, Blame! and So On contains artwork and sketches for Blame!, Noise, and Wolverine: Snikt!, amongst others; it also contains the illustrations Nihei provided for Bitch's Life and the aborted Dead Heads as thumbnails.