Dexetimide

Dexetimide
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N04AA08 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances);
Identifiers
	IUPAC name 3-(1-benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione;
CAS Number	21888-98-2 ;
PubChem CID	30843;
IUPHAR/BPS	354;
DrugBank	DB08997 ;
ChemSpider	28615 ;
UNII	43477QYX3D;
KEGG	D03711 ;
ChEMBL	ChEMBL1908364 ;
CompTox Dashboard (EPA)	DTXSID701043218 ;
Chemical and physical data
Formula	C23H26N2O2
Molar mass	362.473 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2NC(=O)CCC2(c1ccccc1)C4CCN(Cc3ccccc3)CC4;
	InChI InChI=1S/C23H26N2O2/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,24,26,27)/t23-/m1/s1 ; Key:LQQIVYSCPWCSSD-HSZRJFAPSA-N ;
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Dexetimide (brand name Tremblex) is a piperidine anticholinergic. It is a muscarinic antagonist that is used to treat drug induced parkinsonism. Dexetimide was discovered at Janssen Pharmaceutica in 1968.^[2]^[3]

References

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Dom R, Van Lommel R, Baro F (1971). "A quantitative study of neuroleptic-induced extrapyramidal symptoms and their response to dexetimide, a potent and long-acting antiparkinsonian agent". Acta Psychiatrica Scandinavica. 47 (4): 399–410. doi:10.1111/j.1600-0447.1971.tb03697.x. PMID 4947805. S2CID 10591790.
^ Huygens H, Vereecken JL, Tanghe A (1973). "Dexetimide (R 16470) in the control of neuroleptic-induced extrapyramidal side-effects. Its prophylactic value and duration of action". Psychiatria, Neurologia, Neurochirurgia. 76 (4): 251–9. PMID 4581374.

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