Pirenzepine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Pirenzepine
Pirenzepine.png
Systematic (IUPAC) name
11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Clinical data
AHFS/Drugs.com monograph
Legal status ?
Identifiers
CAS number 28797-61-7 YesY
ATC code A02BX03
PubChem CID 4848
IUPHAR ligand 328
DrugBank DB00670
ChemSpider 4682 YesY
UNII 3G0285N20N YesY
KEGG D08389 YesY
ChEBI CHEBI:8247 YesY
ChEMBL CHEMBL9967 YesY
Chemical data
Formula C19H21N5O2 
Mol. mass 351.403 g/mol
 YesY (what is this?)  (verify)

Pirenzepine (Gastrozepin), an M1 selective antagonist, is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm. It is in a class of drugs known as muscarinic receptor antagonists - acetylcholine being the neurotransmitter of the parasympathetic nervous system which initiates the rest-and-digest state (as opposed to fight-or-flight), the result being an increase in gastric motility and digestion.[1] It has no effects on the brain and spinal cord as it cannot diffuse through the blood–brain barrier.

Pirenzepine has been investigated for use in myopia control.[2][3]

See also[edit]

References[edit]

  1. ^ Stolerman, Ian P. (2 August 2010). Encyclopedia of Psychopharmacology. Springer. p. 811. ISBN 978-3-540-68698-9. Retrieved 26 June 2013. 
  2. ^ Czepita D (2005). "Fundamentals of modern treatment of myopia". Ann Acad Med Stetin 51 (2): 5–9. PMID 16519089. 
  3. ^ Walline JJ, Lindsley K, Vedula SS, Cotter SA, Mutti DO, Twelker JD (2011). "Interventions to slow progression of myopia in children". Cochrane Database Syst Rev (12): CD004916. doi:10.1002/14651858.CD004916.pub3. PMID 22161388.