ZINC17988990

ZINC17988990
Identifiers
	IUPAC name (4-oxo-5-phenyl-3H-thieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-1,4-benzoxazin-4-yl)propanoate;
PubChem CID	27791261;
ChemSpider	22546450;
Chemical and physical data
Formula	C24H19N3O5S
Molar mass	461.49 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1C(=O)N(C2=CC=CC=C2O1)CCC(=O)OCC3=NC4=C(C(=CS4)C5=CC=CC=C5)C(=O)N3;
	InChI InChI=1S/C24H19N3O5S/c28-20-13-31-18-9-5-4-8-17(18)27(20)11-10-21(29)32-12-19-25-23(30)22-16(14-33-24(22)26-19)15-6-2-1-3-7-15/h1-9,14H,10-13H2,(H,25,26,30); Key:YOFCRYWWKQMPEW-UHFFFAOYSA-N;

ZINC17988990 is a drug which acts as a potent and selective inhibitor for the TRPV5 calcium channel, with an IC₅₀ of 177nM and high selectivity for TRPV5 over TRPV6 and the other subtypes of TRPV. It is the first selective inhibitor to be developed for TRPV5, and may be useful for modulating calcium reabsorption in the kidneys.^[1]

References

^ Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC, et al. (October 2019). "Structure-based characterization of novel TRPV5 inhibitors". eLife. 8. doi:10.7554/eLife.49572. PMC 6834369. PMID 31647410.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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[pmid31647410-1] Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC, et al. (October 2019). "Structure-based characterization of novel TRPV5 inhibitors". eLife. 8. doi:10.7554/eLife.49572. PMC 6834369. PMID 31647410.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[1]

See also

References